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(E/Z)-Demethoxycurcumin

Name: (E/Z)-Demethoxycurcumin
Brand: TargetMol
SKU: T4803
Price: 783 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: (E/Z)-去甲氧基姜黄素

货号 T4803Cas号 24939-17-1 一键复制产品信息纯度: 99.98%

很棒

(p-Hydroxycinnamoyl)feruloylmethane 是一种分离于姜黄属植物中的姜黄素，具有抗凝血作用。

(E/Z)-Demethoxycurcumin

一键复制产品信息

很棒

纯度: 99.98%

货号 T4803Cas号 24939-17-1

别名 (E/Z)-去甲氧基姜黄素

(p-Hydroxycinnamoyl)feruloylmethane 是一种分离于姜黄属植物中的姜黄素，具有抗凝血作用。

规格	价格	库存
1 mg	¥ 783	现货
5 mg	¥ 1,990	现货
10 mg	¥ 2,820	现货
25 mg	¥ 4,590	现货
50 mg	¥ 6,430	现货
100 mg	¥ 8,670	现货
1 mL x 10 mM (in DMSO)	¥ 1,980	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.98%

颜色: 红色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

(E/Z)-Demethoxycurcumin AI Summary

(E/Z)-Demethoxycurcumin exhibits diverse bioactivities and cytotoxic effects across various human cell lines. It demonstrates significant cytotoxicity as evident from MTT assay results with IC50 values of 92100 nM against MCF7 cells, 26300 nM against WRL68 cells, and 28200 nM against A549 cells, indicative of its potential to inhibit cell growth. Additionally, it reduces UPA expression in HT1080 cells with an IC50 of 7500 nM and increases MMP3 levels in MDA-MB-231 cells after 24 hours with an IC50 of 9000000 nM. (E/Z)-Demethoxycurcumin induces apoptosis in SKOV3 cells at various concentrations, showing 70.7% activity at 80 µM, 35.1% at 20 µM, and 51.5% at 40 µM after 48 hours. The compound also displays significant inhibitory activity against the SARS-CoV-2 3CL protease with a percentage inhibition of -6.76% at 20 µM, and exhibits a 0.28% inhibition rate of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours exposure. Furthermore, it inhibits Staphylococcus aureus SrtA enzyme activity with an IC50 of 70300 nM and has antibacterial activity with a MIC value greater than 543300 nM. In terms of enzyme inhibition, (E/Z)-Demethoxycurcumin acts as an inhibitor of human MAO-A with a Ki value of 910 nM and MAO-B with an IC50 of 2450 nM. Lastly, it shows cytotoxicity against human HepG2 cells with an IC50 of 11500 nM as measured by the CellTiter-Glo luminescent cell viability assay, highlighting its effectiveness in diminishing cell viability..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(p-Hydroxycinnamoyl)feruloylmethane is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.
别名	(E/Z)-去甲氧基姜黄素

化学信息

分子量	338.35
分子式	C₂₀H₁₈O₅
CAS No.	24939-17-1
Smiles	COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)ccc1O
密度	1.282g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 55 mg/mL (162.55 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9555 mL	14.7776 mL	29.5552 mL	147.7760 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL	29.5552 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL	14.7776 mL
20 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3888 mL
50 mM	0.0591 mL	0.2956 mL	0.5911 mL	2.9555 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4778 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit (E/Z)-Demethoxycurcumin (E/Z)Demethoxycurcumin (E/Z) Demethoxycurcumin

(E/Z)-Demethoxycurcumin

(E/Z)-Demethoxycurcumin