(E/Z)-Demethoxycurcumin

Name: (E/Z)-Demethoxycurcumin
Brand: TargetMol
SKU: T4803
Price: 783 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.76%

货号 T4803Cas号 24939-17-1

别名 (E/Z)-去甲氧基姜黄素

(p-Hydroxycinnamoyl)feruloylmethane 是一种分离于姜黄属植物中的姜黄素，具有抗凝血作用。

(E/Z)-Demethoxycurcumin

一键复制产品信息

很棒

纯度: 98.76%

货号 T4803 别名 (E/Z)-去甲氧基姜黄素Cas号 24939-17-1

(p-Hydroxycinnamoyl)feruloylmethane 是一种分离于姜黄属植物中的姜黄素，具有抗凝血作用。

规格	价格	库存
1 mg	¥ 783	现货
5 mg	¥ 1,990	现货
10 mg	¥ 2,820	现货
25 mg	¥ 4,590	现货
50 mg	¥ 6,430	现货
100 mg	¥ 8,670	现货
1 mL x 10 mM (in DMSO)	¥ 1,980	现货

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纯度: 98.76%

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COA HNMR HPLC 产品操作手册

产品介绍

(E/Z)-Demethoxycurcumin AI Summary

(E/Z)-Demethoxycurcumin exhibits diverse bioactivities and cytotoxic effects across various human cell lines. It demonstrates significant cytotoxicity as evident from MTT assay results with IC50 values of 92100 nM against MCF7 cells, 26300 nM against WRL68 cells, and 28200 nM against A549 cells, indicative of its potential to inhibit cell growth. Additionally, it reduces UPA expression in HT1080 cells with an IC50 of 7500 nM and increases MMP3 levels in MDA-MB-231 cells after 24 hours with an IC50 of 9000000 nM. (E/Z)-Demethoxycurcumin induces apoptosis in SKOV3 cells at various concentrations, showing 70.7% activity at 80 µM, 35.1% at 20 µM, and 51.5% at 40 µM after 48 hours. The compound also displays significant inhibitory activity against the SARS-CoV-2 3CL protease with a percentage inhibition of -6.76% at 20 µM, and exhibits a 0.28% inhibition rate of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours exposure. Furthermore, it inhibits Staphylococcus aureus SrtA enzyme activity with an IC50 of 70300 nM and has antibacterial activity with a MIC value greater than 543300 nM. In terms of enzyme inhibition, (E/Z)-Demethoxycurcumin acts as an inhibitor of human MAO-A with a Ki value of 910 nM and MAO-B with an IC50 of 2450 nM. Lastly, it shows cytotoxicity against human HepG2 cells with an IC50 of 11500 nM as measured by the CellTiter-Glo luminescent cell viability assay, highlighting its effectiveness in diminishing cell viability..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(p-Hydroxycinnamoyl)feruloylmethane is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.
别名	(E/Z)-去甲氧基姜黄素

化学信息

分子量	338.35
分子式	C₂₀H₁₈O₅
CAS No.	24939-17-1
Smiles	COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)ccc1O
密度	1.282g/cm3
颜色	Red
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (162.55 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9555 mL	14.7776 mL	29.5552 mL	147.7760 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL	29.5552 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL	14.7776 mL
20 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3888 mL
50 mM	0.0591 mL	0.2956 mL	0.5911 mL	2.9555 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4778 mL