4-Hydroxycoumarin

Name: 4-Hydroxycoumarin
Brand: TargetMol
SKU: PDK0015
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 PDK0015Cas号 1076-38-6

别名 4-羟基香豆素

4-Hydroxycoumarin 是香豆素衍生物，也是通用的杂环支架之一，具有亲电和亲核性质。

4-Hydroxycoumarin

一键复制产品信息

很棒

货号 PDK0015 别名 4-羟基香豆素Cas号 1076-38-6

4-Hydroxycoumarin 是香豆素衍生物，也是通用的杂环支架之一，具有亲电和亲核性质。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 135	现货

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纯度: ≥98%

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产品介绍

4-Hydroxycoumarin AI Summary

4-Hydroxycoumarin exhibits a broad spectrum of biological activities including notable inhibitory activity against various enzymes, antioxidant properties, cytotoxicity against human and mouse cell lines, and specific bioactivities relevant to pharmaceutical and agricultural applications. Specifically, it inhibits HIV-1 integrase with an IC50 value greater than 100,000 nM and xanthine oxidase with an IC50 value of 195,000 nM. It shows antioxidant activity by scavenging DPPH and ABTS radicals, inhibiting hydroxyl radical production, and demonstrating a trolox equivalent antioxidant capacity of 186.0 umolequiv/g in the ABTS assay. The compound also displays notable inhibition against several human carbonic anhydrases, particularly CA9 (Ki = 410.0 nM) and moderate activity against CA1 (Ki = 95,000.0 nM). 4-Hydroxycoumarin is cytotoxic to various human and mouse cell lines, including TK10, UACC62, MCF7, and B16F10, with IC50 values ranging from 600.0 nM to over 200,000.0 nM, indicating varying degrees of potency. It shows some selectivity in its anticancer activity against melanoma cell lines SK-MEL3 (IC50 = 2100.0 nM) and SK-MEL-28 (IC50 = 1300.0 nM). The compound also exhibits antifungal activity against Aspergillus fumigatus at lower concentrations and stimulatory activity on the growth of Colletotrichum acutatum. Additionally, 4-Hydroxycoumarin displays bioactivity in expressed human recombinant UGT enzymes, specifically showing activity in UGT1A7, UGT1A8, and UGT2A1. It provides gastric cytoprotection in male Wistar rats with a cytoprotective effect score of 4.62. The compound also inhibits alpha-glucosidase enzyme with an IC50 value of 400,000 uM and demonstrates binding affinity to CK2alpha as indicated by a delta melting temperature of 3.8 degrees Celsius. Overall, 4-Hydroxycoumarin shows potential for further development in various therapeutic and agricultural domains due to its diverse bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.
别名	4-羟基香豆素

化学信息

分子量	162.14
分子式	C₉H₆O₃
CAS No.	1076-38-6
Smiles	OC1=CC(=O)OC2=CC=CC=C12
密度	1.1734 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Methanol: 20 mg/mL (123.35 mM), Sonication is recommended.

DMSO: 50 mg/mL (308.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.34 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1675 mL	30.8375 mL	61.6751 mL	308.3755 mL
5 mM	1.2335 mL	6.1675 mL	12.3350 mL	61.6751 mL
10 mM	0.6168 mL	3.0838 mL	6.1675 mL	30.8375 mL
20 mM	0.3084 mL	1.5419 mL	3.0838 mL	15.4188 mL
50 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
100 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0838 mL