购物车

您的购物车当前为空

Thio-TEPA

Name: Thio-TEPA
Brand: TargetMol
SKU: T1250
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.07%

货号 T1250Cas号 52-24-4

别名 三亚乙基硫代磷酰胺, Triethylenethiophosphoramide, Tiofosyl, Tiofosfamid

Thio-TEPA (Tiofosyl) 是一种具有抗肿瘤作用的 DNA 烷化剂。

为众多的药物研发团队赋能，

让新药发现更简单！

Thio-TEPA

一键复制产品信息

很棒

纯度: 99.07%

货号 T1250 别名 三亚乙基硫代磷酰胺, Triethylenethiophosphoramide, Tiofosyl, TiofosfamidCas号 52-24-4

Thio-TEPA (Tiofosyl) 是一种具有抗肿瘤作用的 DNA 烷化剂。

规格	价格	库存
5 mg	¥ 315	现货
10 mg	¥ 453	现货
25 mg	¥ 747	现货
50 mg	¥ 1,160	现货
100 mg	¥ 1,890	现货
200 mg	¥ 2,850	现货
500 mg	¥ 4,630	现货
1 mL x 10 mM (in DMSO)	¥ 822	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.07%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Thio-TEPA AI Summary

Thio-TEPA demonstrates a wide range of bioactivities and pharmacokinetic properties suggestive of its potential as a therapeutic agent. In in vivo studies, it exhibits significant antineoplastic effects, particularly against P388 leukemia and L1210 leukemia in CD2F1 male mice, with an increase in life span (ILS) of up to 141.0% and a T/C ratio of 155.0%. It has an optimal dosing of 6 mg/kg/day and showcases a therapeutic ratio of 2.75 and LD50 of 18.0 mg/kg. The compound has shown activity in additional cancer models, including cytotoxic effects against various human tumor cell lines such as breast, renal, non-small cell lung, leukemia, melanoma, central nervous system, prostate, and colon cell lines, with IC50 values ranging from 1400.0 nM to 6970.0 nM. Pharmacokinetically, Thio-TEPA has a total body clearance rate of 6.7 mL/min/kg and a renal clearance of 0.03 mL/min/kg in humans. It also exhibits a volume of distribution at steady state of 1.6 L/kg and a half-life of 2.7 hours. Mechanistically, Thio-TEPA inhibits various enzymes and transporters, including human cytochrome P450 2B6, rat cytochrome P450 2B1, and human liver OATP transporters, showing varying degrees of inhibition. It also shows a high partition ratio in both human and rat cytochrome P450 2B6. Additionally, it has demonstrated inhibitory activity against human BSEP with an IC50 value greater than 135000.0 nM and antiviral activity against SARS-CoV-2 by reducing induced cytotoxicity of virus-exposed cells. Furthermore, Thio-TEPA indicates liver toxicity in humans and moderate to severe hepatotoxicity in preclinical models. It has been associated with a drug-induced liver injury severity class index of 3.0 and various levels of specific liver toxicities. In summary, Thio-TEPA is a multi-faceted therapeutic agent with significant antitumor, enzyme inhibition, transporter inhibition, and potential antiviral activities, along with notable pharmacokinetic and hepatotoxic profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
别名	三亚乙基硫代磷酰胺, Triethylenethiophosphoramide, Tiofosyl, Tiofosfamid

化学信息

分子量	189.22
分子式	C₆H₁₂N₃PS
CAS No.	52-24-4
Smiles	P(=S)(N1CC1)(N2CC2)N3CC3
密度	1.5g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 91 mg/mL (480.92 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (17.44 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2849 mL	26.4243 mL	52.8485 mL	264.2427 mL
5 mM	1.0570 mL	5.2849 mL	10.5697 mL	52.8485 mL
10 mM	0.5285 mL	2.6424 mL	5.2849 mL	26.4243 mL
20 mM	0.2642 mL	1.3212 mL	2.6424 mL	13.2121 mL
50 mM	0.1057 mL	0.5285 mL	1.0570 mL	5.2849 mL
100 mM	0.0528 mL	0.2642 mL	0.5285 mL	2.6424 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。