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Dimenhydrinate

Name: Dimenhydrinate
Brand: TargetMol
SKU: T0298
Price: 226 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 乘晕宁, 茶苯海明, Vomex A, Dramamine, Chloranautine

货号 T0298Cas号 523-87-5 一键复制产品信息纯度: 99.77%

很棒

Dimenhydrinate (Vomex A) 是一种乙醇胺和组胺拮抗剂，具有抗过敏活性，可作为抗催吐剂。

Dimenhydrinate

一键复制产品信息

很棒

纯度: 99.77%

货号 T0298Cas号 523-87-5

别名 乘晕宁, 茶苯海明, Vomex A, Dramamine, Chloranautine

Dimenhydrinate (Vomex A) 是一种乙醇胺和组胺拮抗剂，具有抗过敏活性，可作为抗催吐剂。

规格	价格	库存
100 mg	¥ 328	现货
200 mg	¥ 476	现货
500 mg	¥ 786	现货
1 mL x 10 mM (in DMSO)	¥ 226	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.77%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Dimenhydrinate AI Summary

Dimenhydrinate exhibits a diverse range of bioactivities across multiple biochemical assays and targets. It demonstrates significant potency in inducing erasure of genomic imprints, inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1), and Hydroxyacyl-Coenzyme A Dehydrogenase, Type II (HADH2). Additionally, it is a substrate of Cytochrome P450 2D6 and shows bioactivity in Cytochrome panel assays. The compound acts as an agonist for androgen receptor signaling and the antioxidant response element (ARE) signaling pathway. Moreover, it inhibits the human hERG channel activity and the ROR-gamma signaling pathway. Dimenhydrinate has activity against various adrenergic receptors, the norepinephrine transporter, calcium channel Type L, and dopamine transporter. It also shows notable activity in histamine H1 receptor, serotonin receptor subtypes (5-HT2A, 5-HT2B, and 5-HT2C), and Sigma1 receptor binding assays, indicating broad pharmacological effects. It further inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells. Evaluation in DrugMatrix assays illustrates alterations in several physiological parameters like liver enzymes, kidney function markers, electrolytes, lipid profiles, hematological parameters, and immune cell counts, suggesting potential effects on liver and kidney function, blood composition, and immune response. For biliary transport, Dimenhydrinate shows weak or no inhibitory effect on human BSEP, MRP2, MRP3, and MRP4 activities, with IC50 values substantially higher than effective concentrations. It induces no drug-induced liver injury. In antiviral studies, Dimenhydrinate shows moderate to weak inhibition of SARS-CoV-2 cytotoxicity and 3CL-Pro protease activity, identifiable by varying inhibition values across different assays at tested concentrations. The compound has also shown selective inhibition of the HDAC6 enzyme, suggesting potential as an HDAC6 inhibitor based on assays utilizing different peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity.
别名	乘晕宁, 茶苯海明, Vomex A, Dramamine, Chloranautine

化学信息

分子量	469.96
分子式	C₂₄H₂₈ClN₅O₃
CAS No.	523-87-5
Smiles	Cn1c2c([nH]c(Cl)n2)c(=O)n(C)c1=O.CN(C)CCOC(c1ccccc1)c1ccccc1
密度	1.2586 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (127.67 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1278 mL	10.6392 mL	21.2784 mL	106.3920 mL
5 mM	0.4256 mL	2.1278 mL	4.2557 mL	21.2784 mL
10 mM	0.2128 mL	1.0639 mL	2.1278 mL	10.6392 mL
20 mM	0.1064 mL	0.5320 mL	1.0639 mL	5.3196 mL
50 mM	0.0426 mL	0.2128 mL	0.4256 mL	2.1278 mL
100 mM	0.0213 mL	0.1064 mL	0.2128 mL	1.0639 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit HistamineReceptor Histamine Receptor H1 receptor Dimenhydrinate

Dimenhydrinate

Dimenhydrinate

Dimenhydrinate 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

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