购物车

您的购物车当前为空

Rubitecan

Name: Rubitecan
Brand: TargetMol
SKU: T5853
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 97.54%

货号 T5853Cas号 91421-42-0

别名 鲁比特康, RFS 2000, 9-Nitrocamptothecin

Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。

为众多的药物研发团队赋能，

让新药发现更简单！

Rubitecan

一键复制产品信息

很棒

纯度: 97.54%

货号 T5853 别名 鲁比特康, RFS 2000, 9-NitrocamptothecinCas号 91421-42-0

规格	价格	库存
1 mg	¥ 137	现货
5 mg	¥ 289	现货
10 mg	¥ 413	现货
25 mg	¥ 782	现货
50 mg	¥ 1,130	现货
100 mg	¥ 1,760	现货
200 mg	¥ 2,590	现货
1 mL x 10 mM (in DMSO)	¥ 318	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.54%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Rubitecan AI Summary

Rubitecan is a lactone compound that exhibits a wide range of biological activities. It has demonstrated significant antitumor effects against P-338 leukemia in mice, extending the survival time of treated animals to 348% of control animals and achieving 5 cures within an active dose range of 2.5 to 20 mg/kg, with a toxic dose of 40 mg/kg. In lactone metabolism studies, Rubitecan causes a rapid decrease in lactone levels in human and mouse plasma, reaching 0% in humans and 18-30% in mice within a few hours. The compound shows potency in inhibiting ROR gamma transcriptional activity (89.1 nM to 631.0 nM), activities against the malarial parasite plastid, and inhibition of USP1/UAF1 (63095.7 nM). It induces apoptosis in human Caco2 cells with IC50 values between 112.0 nM and 479.0 nM and is active in assays involving Schwann cells and colon adenocarcinoma cells. Rubitecan also inhibits various human multidrug resistance-associated proteins (MRP2, MRP3, and MRP4) with varying IC50 values and has weak activity against human BSEP. While showing no significant antifungal or antibacterial effects, Rubitecan exhibits antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, showing a reduction in cytotoxicity by 37.5% in Caco-2 cells but with relatively high IC50 values indicating weaker potency. Additionally, Rubitecan has limited binding affinity towards various human receptors and enzymes, with non-significant activity levels in most cases. It exhibits some antagonistic activity at human TBXA2R and weak inhibitory effects on human ACHE, but these are not prominent compared to its other bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Rubitecan (9-Nitrocamptothecin) is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
别名	鲁比特康, RFS 2000, 9-Nitrocamptothecin

化学信息

分子量	393.35
分子式	C₂₀H₁₅N₃O₆
CAS No.	91421-42-0
Smiles	CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
密度	1.63g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (127.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.17 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5423 mL	12.7113 mL	25.4227 mL	127.1133 mL
5 mM	0.5085 mL	2.5423 mL	5.0845 mL	25.4227 mL
10 mM	0.2542 mL	1.2711 mL	2.5423 mL	12.7113 mL
20 mM	0.1271 mL	0.6356 mL	1.2711 mL	6.3557 mL
50 mM	0.0508 mL	0.2542 mL	0.5085 mL	2.5423 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2711 mL