规格

价格

库存

数量

1 mg

¥ 346

现货

5 mg

¥ 826

现货

10 mg

¥ 1,230

现货

25 mg

¥ 2,090

现货

50 mg

¥ 3,480

现货

100 mg

¥ 4,960

现货

200 mg

¥ 6,860

现货

1 mL x 10 mM (in DMSO)

¥ 987

现货

生物活性

产品描述	Lefamulin acetate (BC-3781 acetate) (formally BC-3781 acetate) is a novel pleuromutilin antibiotic and is the first to be used for the systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer. Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment.
体外活性	Lefamulin对革兰阴性菌有抗菌作用，包括流感嗜血杆菌（MIC50=1 μg/ml；MIC90=0.12 μg/ml）和摩拉氏卡他球菌（MIC50=2 μg/ml；MIC90=0.25 μg/ml）[1]。Lefamulin acetate（BC-3781 acetate）对耐药的革兰阳性菌也有抗菌活性，包括金黄色葡萄球菌（MRSA）（MIC50=0.12 μg/ml；MIC90=0.25 μg/ml）；β-溶血性链球菌（MIC50=0.03 μg/ml；MIC90=0.03 μg/ml）；绿色链球菌群（MIC50=0.12 μg/ml；MIC90=0.5 μg/ml）；粪肠球菌（MIC50=0.12 μg/ml；MIC90=4 μg/ml）；肺炎链球菌（MIC50=0.12 μg/ml；MIC90=0.25 μg/ml）[1]。
别名	醋酸来法莫林, BC-3781 acetate

化学信息

分子量	567.78
分子式	C₃₀H₄₉NO₇S
CAS No.	1350636-82-6
Smiles	CC(O)=O.[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 99 mg/mL (174.36 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.81 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO