规格

价格

库存

数量

1 mg

¥ 2,330

现货

5 mg

¥ 5,630

现货

10 mg

¥ 7,880

现货

25 mg

¥ 11,700

现货

50 mg

¥ 15,300

现货

100 mg

¥ 19,500

现货

1 mL x 10 mM (in DMSO)

¥ 5,850

现货

生物活性

产品描述	Relutrigine (PRAX-562) is an orally active, long-acting sodium current inhibitor that preferentially suppresses sustained INa induced by TX-II or SCN8A N1768D mutations (IC50=141/75 nM). It reduces neuronal intrinsic excitability and may be used for anticonvulsant therapy.
体外活性	Relutrigine (0.001-10000 µM) 对hNaV1.6持续钠通道具有抑制作用，具有持久INa偏好。Relutrigine (0.3 µM) 显著降低野生型 CA1 锥体神经元的内在兴奋性[1]。
体内活性	Relutrigine (0.3-40 mg/kg；口服；单次给药) 在雄性 CD-1 小鼠内，剂量依赖性地保护最大电休克发作 (MES) 诱导的强直性后肢癫痫[1]。
别名	PRAX-562, PRAX562, PRAX 562

化学信息

分子量	407.27
分子式	C₁₅H₁₁F₆N₅O₂
CAS No.	2392951-29-8
Smiles	C(OCC)(F)(F)C=1N2C(=NN1)C=NC(=C2)C=3C=C(F)C(OCC(F)(F)F)=NC3
颜色	Orange
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (196.43 mM), Sonication is recommended.

溶液配制表

DMSO