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Jatrorrhizine hydrochloride

Name: Jatrorrhizine hydrochloride
Brand: TargetMol
SKU: T2986
Price: 290 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.22%

货号 T2986Cas号 960383-96-4

Jatrorrhizine hydrochloride 是从小檗的根中提取的化合物，具有具有神经保护、抗菌、抗疟原虫和抗氧化活性。Jatrorrhizine hydrochloride 是一种具有口服活性和选择性的乙酰胆碱酯酶 (AChE)抑制剂，抑制去甲肾上腺素 (NE) 的摄取。

Jatrorrhizine hydrochloride

一键复制产品信息

很棒

纯度: 99.22%

货号 T2986Cas号 960383-96-4

规格	价格	库存	数量
20 mg	¥ 290	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.22%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Jatrorrhizine hydrochloride AI Summary

Jatrorrhizine hydrochloride exhibits a broad spectrum of bioactivities, most notably antimalarial and anti-HIV activities. It shows significant in vitro antimalarial activity against Plasmodium falciparum strains D6 and W2 with IC50 values of 0.422 ug/mL and 1.607 ug/mL, respectively. Additionally, it demonstrates antiplasmodial activity against the multi-drug-resistant Plasmodium falciparum K1 strain with an IC50 of 3150.0 nM and against the drug-susceptible 3D7 strain with an EC50 of 939.0 nM. In terms of HIV inhibition, Jatrorrhizine hydrochloride inhibits HIV1 reverse transcriptase activity with an IC50 of 71.0 ug/mL. The compound also displays antiamnesic activity against Entamoeba histolytica NIH 200 and some cytotoxicity towards human KB cells and Huh7 hepatocellular carcinoma cells, with IC50 values of 82700.0 nM and 8940.0 nM, respectively. Furthermore, it exhibits estrogenic activity at ERalpha in human MVLN cells, with activities of 71.19% at 100 ug/mL and 52.2% at 20 ug/mL. In terms of physicochemical properties, Jatrorrhizine hydrochloride has varying solubility levels in different pH conditions (1300000.0 nM to 1500000.0 nM), log P values ranging from 0.1 to -1.5, log D values from -1.5 to 0.6, a binding affinity to bovine serum albumin with a Kb value of 1.73 x 10^-3 L/mol, and a dissociation constant pKa of 9.6..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).

化学信息

分子量	373.83
分子式	C₂₀H₂₀ClNO₄
CAS No.	960383-96-4
Smiles	c12c(c(c(cc1)OC)OC)c[n+]1c(c2)c2c(CC1)cc(c(c2)OC)O.[Cl-]
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 3.33 mg/mL (8.91 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6750 mL	13.3751 mL	26.7501 mL	133.7506 mL
5 mM	0.5350 mL	2.6750 mL	5.3500 mL	26.7501 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Jatrorrhizine hydrochloride Cholinesterase Bacterial 5HTReceptor 5-HT Receptor 5HT Receptor

Jatrorrhizine hydrochloride

Jatrorrhizine hydrochloride