Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50% [1]. Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells [1]. Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88% [1]. Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC 50 : 0.29 μΜ) [1]. Cell Proliferation Assay [1] Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells. Concentration: 0-10 μΜ Incubation Time: 72 h Result: Inhibited cell proliferation to 38%, 0.8%, 7.1%, 30.5% at 1 μΜ, respectively. IC 50 s: 0.04, 0.02, 0.02, 0.03 μΜ, respectively. Cell Cycle Analysis [1] Cell Line: VL51 and MINO cells Concentration: 50 and 500 nM Incubation Time: 24, 48 and 72 h Result: Arrested cell in G2/M phase.