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Fumaric acid

Name: Fumaric acid
Brand: TargetMol
SKU: T3763
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.80%

货号 T3763Cas号 110-17-8

别名 富马酸, 反丁烯二酸, Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acid

Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。

Fumaric acid

一键复制产品信息

很棒

纯度: 98.80%

货号 T3763 别名 富马酸, 反丁烯二酸, Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acidCas号 110-17-8

Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。

规格	价格	库存	数量
5 g	¥ 99	现货

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纯度: 98.80%

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COA LCMS HNMR 产品操作手册

产品介绍

生物活性

产品描述

Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.

别名

富马酸, 反丁烯二酸, Trans-Butenedioic acid, Lichenic acid, Fumarate, Donitic acid, Allomaleic acid, 2-Butenedioic acid

化学信息

分子量	116.07
分子式	C₄H₄O₄
CAS No.	110-17-8
Smiles	C(=C/C(O)=O)\C(O)=O
密度	1.64. Temperature:20 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 62.5 mg/mL (538.47 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.6155 mL	43.0775 mL	86.1549 mL	430.7745 mL
5 mM	1.7231 mL	8.6155 mL	17.2310 mL	86.1549 mL
10 mM	0.8615 mL	4.3077 mL	8.6155 mL	43.0775 mL
20 mM	0.4308 mL	2.1539 mL	4.3077 mL	21.5387 mL
50 mM	0.1723 mL	0.8615 mL	1.7231 mL	8.6155 mL
100 mM	0.0862 mL	0.4308 mL	0.8615 mL	4.3077 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Fumaric acid is a multifaceted chemical that exhibits a broad range of bioactivities. In the context of Xenopus oocytes, it inhibits the Oat1-mediated [3H]PAH uptake with Ki values around 616,000 nM, while showing very weak inhibition of Oat6-mediated [3H]ES uptake with Ki values exceeding 31,622,776 nM. Additionally, it impacts 2-oxoglutarate-dependent human JMJD2E and human recombinant HIF PHD2, with IC50 values of 2,300,000 nM and 19,000 nM, respectively. In assays involving human recombinant PHD2 expressed in Escherichia coli, Fumaric acid exhibits an IC50 of 19,090 nM and demonstrates inhibition of the enzyme with a half-life of 6 hours. It is also a selective inhibitor of carbonic anhydrase isoforms, specifically showing more potent inhibition towards carbonic anhydrase 2 (Kinact of 10.5 μM) than isoform 1 (Kinact of 395 μM). Fumaric acid manifests other notable bioactivities, including agonism of the Thyroid Stimulating Hormone Receptor, and antagonism of the retinoid-related orphan receptor gamma. It induces DNA re-replication in SW480 colon adenocarcinoma cells and exhibits activity against HP1-beta Chromodomain interactions and ELG1-dependent DNA repair processes in HEK293T cells. Moreover, it shows moderate liver toxicity, confirmed by elevated serum activity levels of ALT or AST in 59% of clinical trial cases, without causing any acute liver toxicity or other severe liver conditions. Additionally, it inhibits urease activity in bacterial strains and human FBPase, and shows interaction with bacterial and human enzymes including FBPase and recombinant PHDs, with varying degrees of efficacy. Fumaric acid also demonstrates binding affinity towards several human receptors, exuding a manifold interaction profile across multiple biological pathways, indicating potential therapeutic applications contingent upon further detailed evaluations..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl