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5-Hydroxyflavone

Name: 5-Hydroxyflavone
Brand: TargetMol
SKU: T8190
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.96%

货号 T8190Cas号 491-78-1

别名 5-羟基黄酮

5-Hydroxyflavone 是类黄酮配体，对 FaDU，MCF-7，U87，MDA-MB-435S，RPE-1 和 HEK293 细胞没有细胞毒性。

为众多的药物研发团队赋能，

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5-Hydroxyflavone

一键复制产品信息

很棒

纯度: 99.96%

货号 T8190 别名 5-羟基黄酮Cas号 491-78-1

5-Hydroxyflavone 是类黄酮配体，对 FaDU，MCF-7，U87，MDA-MB-435S，RPE-1 和 HEK293 细胞没有细胞毒性。

规格	价格	库存
5 mg	¥ 123	现货
10 mg	¥ 166	现货
25 mg	¥ 255	现货
50 mg	¥ 413	现货
100 mg	¥ 662	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.59%

颜色: 白色至黄色

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

5-Hydroxyflavone AI Summary

5-Hydroxyflavone exhibits a diverse range of bioactivities across various biological systems. It acts as an inhibitor of COX-2 catalyzed PGE-2 production, showing a 45.0% inhibition at 10 µM concentration in LPS-induced RAW 264.7 cells. The compound demonstrates binding affinity to multiple receptors, including the benzodiazepine receptor (Ki of 1900 nM) and various adenosine receptors with moderate affinity (Ki values: 2170 nM for A1, 6200 nM for A2A, and displaces 47.0% of [125I]AB-MECA binding from A3 receptor). In mitochondrial enzyme assays, 5-Hydroxyflavone shows significant inhibitory activity, notably on beef heart mitochondrial succinoxidase (95.7%) and rat liver mitochondrial ATPase (98.9%). Additionally, it displays hypochlorous acid scavenging activity with 17.0% inhibition of DHR oxidation at 50 µM. In terms of cytotoxicity, it exhibits an ED50 value of 20.0 µg/ml against human KB cells and enhances DNA cleavage mediated by human DNA topoisomerase 2 in E. coli pUC8 DNA. As an antagonist, it inhibits the androgen receptor with an IC50 of 300 nM and shows agonist activity in glucocorticoid receptor assays. The compound displays gastroprotective effects, providing 58.0% protection from gastric damage in rats at 20 mg/kg intraperitoneally. It also has antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 (IC50 of 65900 nM) and antitrypanosomal activity against Trypanosoma brucei brucei (IC50 < 30000 nM). Furthermore, 5-Hydroxyflavone exhibits antiviral activity against SARS-CoV-2, with an IC50 value greater than 20000 nM and shows potential in modulating lipid storage and activating various enzymes like Cytochrome P450 3A4. Overall, 5-Hydroxyflavone presents a broad pharmacological profile, making it a candidate for further investigation in various therapeutic areas including inflammation, gastroprotection, infectious diseases, and enzyme modulation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	5-Hydroxyflavone is a natural product
别名	5-羟基黄酮

化学信息

分子量	238.24
分子式	C₁₅H₁₀O₃
CAS No.	491-78-1
Smiles	Oc1cccc2oc(cc(=O)c12)-c1ccccc1
密度	1.34g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 2.2 mg/mL (9.23 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

MBLAC2 Inhibitor inhibit 5-Hydroxyflavone 5Hydroxyflavone 5 Hydroxyflavone

5-Hydroxyflavone

5-Hydroxyflavone