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Ellipticine
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很棒纯度: 99.45%
货号 T1166Cas号 519-23-3
别名 玫瑰树碱, NSC 71795, Elliptisine
Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
其他形式的 “Ellipticine”:
Ellipticine
一键复制产品信息 很棒纯度: 99.45%
货号 T1166 别名 玫瑰树碱, NSC 71795, ElliptisineCas号 519-23-3
Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 218 | 现货 | |
| 5 mg | ¥ 497 | 现货 | |
| 10 mg | ¥ 747 | 现货 | |
| 25 mg | ¥ 1,230 | 现货 | |
| 50 mg | ¥ 1,850 | 现货 | |
| 100 mg | ¥ 2,760 | 现货 | |
| 500 mg | ¥ 6,330 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 483 | 现货 |
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产品介绍
Ellipticine AI Summary
Ellipticine exhibits significant cytotoxic and antiproliferative activity across a broad spectrum of human and animal cell lines, suggesting its potential as an anti-cancer agent. The compound has shown cytotoxicity with varying IC50 values depending on the cell type, with notable activities against human cancer cell lines such as A549 (lung cancer), Col2 (colon cancer), SNU-638 (stomach cancer), KB (epidermal carcinoma), and NCI-H187 (small cell lung cancer). In particular, it has demonstrated IC50 values ranging from 0.36 to 0.4 ug/mL against various cancer cell lines. Additionally, Ellipticine has exhibited pKa of 7.4, DNA binding bioactivity with a Log Kd of 5.18, and an increase in the denaturation temperature of calf thymus DNA by 9.8°C. Other significant activities include its effectiveness against murine leukemia L1210 cells both in vitro and in mice, enhancement of mean life span in treated mice, and inhibition of cellular protein synthesis in assays. Moreover, the compound has also shown activity against Plasmodium falciparum, indicating potential antiparasitic properties. Overall, Ellipticine demonstrates broad-spectrum cytotoxic effects and notable bioactivities, contributing to its attractiveness as a candidate for cancer and antiparasitic therapy..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-60, Breast adenocarcinoma MCF-7, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-4, Neuroblastoma UKF-NB-3, and Glioblastoma U87 mg cell, respectively. |
| 靶点活性 | IMR-32 cells:0.27±0.02μM, MCF-7 cells:1.25±0.13μM, UKF-NB-3 cells:0.44±0.03μM , HL-60 cells (leukemia):0.67±0.06μM, UKF-NB-4 cells:0.49±0.04μM, U-87MG cells (Glioblastoma):1.48±0.62 μM |
| 别名 | 玫瑰树碱, NSC 71795, Elliptisine |
| 分子量 | 246.31 |
| 分子式 | C17H14N2 |
| CAS No. | 519-23-3 |
| Smiles | Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12 |
| 密度 | 1.257g/cm3 |
| 存储 | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | DMSO: 5 mg/mL (20.3 mM), Sonication is recommended.  | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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TCMIP相关数据
中药材来源及性味归经
所属中成药
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 诃子叶 | Terminalia chebula Retz | 温 | 苦 | 肺, 大肠 |
| 化香树叶 | PlatycaryastrobilaceaSieb.etZucc, PlatycaryalongipesWu | 温 | 辛 | 脾, 肾 |
| 龙芽草/仙鹤草 | Agrimonia pilosa Ldb. | 平 | 苦, 涩 | 心, 肝 |
| 芒果叶 | Mangifera indica L.[M.austroyunnanensis Hu] | 平 | 微酸 | |
| 柠檬桉叶 | Eucalyptus citriodora Hook.f.[E.maculata Hook.var.citrioldroa (Hook.f) Bailey] | 微温 | 辛, 苦 | 脾, 胃, 肝 |
| 千屈菜 | Lythrum salicaria L. | 寒 | 苦 | 大肠, 肝 |
| 中成药名称 | 处方组成 | 中成药类型 |
|---|---|---|
| 银花芒果颗粒 | 芒果叶,金银花,蒲公英,桔梗,百部,陈皮,甘草 | 清热药 |
| 山药参芪丸 | 广山药,西洋参,黄芪,天花粉,玉竹,地黄,北沙参,知母,山茱萸,麦冬,芒果叶,红花,丹参,荔枝核,番石榴叶,鸡内金,薄荷脑 | 扶正药 |
| 银花芒果胶囊 | 金银花,芒果叶,蒲公英,桔梗,百部,陈皮,甘草 | 清热药 |
| 银花芒果片 | 金银花,芒果叶,蒲公英,桔梗,百部,陈皮,甘草 | 清热药 |
| 参芪山药膏 | 广山药,人参,天花粉,黄柏,珍珠层粉,黄芪,芒果叶,番石榴叶,阿魏,乳香,没药,人工麝香,红花,肉桂,海龙,海马,冰片,麻油,红丹 | 扶正药 |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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