Iguratimod

Name: Iguratimod
Brand: TargetMol
SKU: T5032
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T5032Cas号 123663-49-0

别名 艾拉莫德, T614

Iguratimod (T614) 是一种抗风湿药，作为 COX-2 的抑制剂，IC50 为 20 μM (7.7 μg/mL)。它还抑制巨噬细胞迁移抑制因子 (MIF)，IC50值为 6.81 μM。

Iguratimod

一键复制产品信息

很棒

纯度: 99.93%

货号 T5032 别名 艾拉莫德, T614Cas号 123663-49-0

Iguratimod (T614) 是一种抗风湿药，作为 COX-2 的抑制剂，IC50 为 20 μM (7.7 μg/mL)。它还抑制巨噬细胞迁移抑制因子 (MIF)，IC50值为 6.81 μM。

规格	价格	库存
1 mg	¥ 315	现货
5 mg	¥ 747	现货
10 mg	¥ 1,230	现货
25 mg	¥ 2,260	现货
50 mg	¥ 3,730	现货
100 mg	¥ 5,330	现货
1 mL x 10 mM (in DMSO)	¥ 822	现货

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产品介绍

Iguratimod AI Summary

Iguratimod exhibits multiple bioactivities, including inhibition of recombinant human Macrophage Migration Inhibitory Factor (MIF) tautomerase activity with an IC50 value of 6810.0 nM, and antiviral activity against SARS-CoV-2. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 14.87% at a 10 uM concentration over 48 hours as determined by high content imaging. It also shows inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM, demonstrating a reduction of 8.67% and 166.31% in two separate FRET-based assays. Additionally, it inhibits SARS-CoV-2 cytotoxicity in VERO-6 cells with an IC50 greater than 20,000 nM. Iguratimod also inhibits human HDAC6 activity by 20.1% using a commercial peptide substrate, while showing a negative inhibition of -12.77% with a custom peptide. Furthermore, it exhibits an agonistic activity towards human ADORA3 with an AC50 of 1435.7 nM and inhibition of human PDE4D with an AC50 of 9800.1 nM, indicating potential in modulating these specific receptors and enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Iguratimod (T614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
靶点活性	MIF:6.81μM, COX-2:20μM
别名	艾拉莫德, T614

化学信息

分子量	374.37
分子式	C₁₇H₁₄N₂O₆S
CAS No.	123663-49-0
Smiles	O=C1C=2C(=CC(NS(C)(=O)=O)=C(OC3=CC=CC=C3)C2)OC=C1NC=O
密度	1.52 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (26.71 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6712 mL	13.3558 mL	26.7115 mL	133.5577 mL
5 mM	0.5342 mL	2.6712 mL	5.3423 mL	26.7115 mL
10 mM	0.2671 mL	1.3356 mL	2.6712 mL	13.3558 mL
20 mM	0.1336 mL	0.6678 mL	1.3356 mL	6.6779 mL