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Racecadotril

Name: Racecadotril
Brand: TargetMol
SKU: T1176
Price: 184 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.66%

货号 T1176Cas号 81110-73-8

别名 消旋卡多曲, Acetorphan

Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。

Racecadotril

一键复制产品信息

很棒

纯度: 99.66%

货号 T1176 别名 消旋卡多曲, AcetorphanCas号 81110-73-8

规格	价格	库存
50 mg	¥ 198	现货
100 mg	¥ 289	现货
200 mg	¥ 424	现货
500 mg	¥ 581	现货
1 g	¥ 897	现货
1 mL x 10 mM (in DMSO)	¥ 184	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.66%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Racecadotril AI Summary

Racecadotril exhibits a broad spectrum of bioactivities and pharmacological properties. Primarily, it demonstrates resistance in drug-resistant human KBV1 and KB-3-1 cells with IC50 values of 1.27 μM and 2.93 μM, respectively. It acts as an inhibitor of Plasmodium falciparum proliferation, displaying potency ranging from 7.5 nM to 23.694.5 nM against different strains of the parasite. Moreover, Racecadotril inhibits human BSEP with an IC50 of 20.3 μM and human MRP2, MRP3, and MRP4 with IC50 values greater than 133 μM, 99 μM, and greater than 133 μM, respectively. The compound shows low activity against SARS-CoV-2 with an inhibition index of 0.3032 in Vero E6 cells and weak antiviral activity (IC50 > 20 μM) in HRCE cells. Racecadotril also displays moderate antifungal activity against Candida albicans and Cryptococcus neoformans, and antibacterial activity against several bacteria, including Escherichia coli and Staphylococcus aureus MRSA. It exhibits weak inhibition of human HDAC6 in an enzymatic assay, showing varying inhibitory percentages depending on the substrate used. Additionally, it acts as an antagonist for several nuclear receptors and shows binding affinity and inhibition for multiple receptors and transporters such as KCNH2, ADRB1, and Ptgs1. Overall, Racecadotril is a multifunctional compound with a wide range of bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
靶点活性	Enkephalinase:4.5 μM
别名	消旋卡多曲, Acetorphan

化学信息

分子量	385.48
分子式	C₂₁H₂₃NO₄S
CAS No.	81110-73-8
Smiles	C(CC1=CC=CC=C1)(C(NCC(OCC2=CC=CC=C2)=O)=O)CSC(C)=O
密度	1.206

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (116.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 71 mg/mL (184.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.19 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5942 mL	12.9708 mL	25.9417 mL	129.7084 mL
5 mM	0.5188 mL	2.5942 mL	5.1883 mL	25.9417 mL
10 mM	0.2594 mL	1.2971 mL	2.5942 mL	12.9708 mL
20 mM	0.1297 mL	0.6485 mL	1.2971 mL	6.4854 mL
50 mM	0.0519 mL	0.2594 mL	0.5188 mL	2.5942 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	1.2971 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Racecadotril Neutral endopeptidase neutral Neprilysin NEP Inhibitor inhibit Endopeptidase Cluster of differentiation 10 CD10 Antidiarrheal

Racecadotril

Racecadotril

Racecadotril 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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