Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PDD00017273 是一种有效的放射增敏作用(二磷酸腺苷核糖)的水解酶 (PARG) 抑制剂,具有抗肿瘤或活性。PDD00017273 具有放射增敏作用,可用于研究上皮性卵巢。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 889 | 现货 | ||
10 mg | ¥ 1,290 | 现货 | ||
25 mg | ¥ 2,180 | 现货 | ||
50 mg | ¥ 3,280 | 现货 | ||
100 mg | ¥ 4,790 | 现货 | ||
500 mg | ¥ 9,870 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 987 | 现货 |
产品描述 | PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries. |
靶点活性 | PARG:1.45 nM (Kd), PARG:26 nM |
体外活性 | PDD 00017273 is an effective inhibitor of PARG with an IC50 of 26 nM and a KD of 1.45 nM. At 10 μM, PDD 00017273 does not inhibit five common cytochrome P450 enzymes. At 30 μM, it moderately increases phosphorylated H2AX (γH2AX) intensity. Additionally, PDD 00017273 reduces NAD/H through PARG inhibition after DNA damage. The compound inhibits ZR-75-1 cells carrying wild-type BRCA1 and BRCA2 and exhibits weaker activity against MDA-MB-436 cells carrying the 5396 + 1G>A mutation in BRCA1[2].At 0.3 μM, PDD 00017273 inhibits the degradation of PAR polymers in MCF7 cells. It also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1-depleted cells. PDD 00017273 halts replication forks and induces DNA damage requiring homologous recombination (HR) for repair[1]. |
分子量 | 514.62 |
分子式 | C23H26N6O4S2 |
CAS No. | 1945950-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (38.86 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9432 mL | 9.7159 mL | 19.4318 mL | 48.5795 mL |
5 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 9.7159 mL | |
10 mM | 0.1943 mL | 0.9716 mL | 1.9432 mL | 4.858 mL | |
20 mM | 0.0972 mL | 0.4858 mL | 0.9716 mL | 2.429 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PDD00017273 1945950-21-9 Others PDD 00017273 PDD-00017273 Inhibitor inhibitor inhibit