Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrphostin AG 538 是一种查尔酮化合物,是一种IGF-1受体激酶抑制剂(IC₅0 :为400 nM),具有有效性、细胞渗透性、可逆性和竞争性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 689 | 现货 | ||
2 mg | ¥ 987 | 现货 | ||
5 mg | ¥ 1,730 | 现货 | ||
10 mg | ¥ 2,590 | 现货 | ||
25 mg | ¥ 4,580 | 现货 | ||
50 mg | ¥ 6,380 | 现货 | ||
100 mg | ¥ 8,590 | 现货 | ||
500 mg | ¥ 17,200 | 现货 |
产品描述 | Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. |
靶点活性 | IGF-1:400 nM, NS3-DNA complex:3.6 μM |
体外活性 | Experimentally it is indeed found that AG 538 does not compete with ATP but competes with the IGF-1R substrate. Both AG 538 and I-OMe AG 538 inhibit IGR-1R autophosphorylation in intact cells in a dose-dependent manner. Both compounds inhibit the activation of the downstream targets PKB and Erk2.[1] |
体内活性 | Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. FP-based assay was chosen to screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds that inhibit NS3-DNA complex formation. Four LOPAC compounds inhibited the FP-based assay: aurintricarboxylic acid (ATA) (IC50=1.4 μM), suramin sodium salt (IC50=3.6 μM), NF 023 hydrate (IC50=6.2 μM) and tyrphostin AG 538 (IC50=3.6 μM).[2] |
别名 | AG 538 |
分子量 | 297.26 |
分子式 | C16H11NO5 |
CAS No. | 133550-18-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (10.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3641 mL | 16.8203 mL | 33.6406 mL | 84.1015 mL |
5 mM | 0.6728 mL | 3.3641 mL | 6.7281 mL | 16.8203 mL | |
10 mM | 0.3364 mL | 1.682 mL | 3.3641 mL | 8.4101 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tyrphostin AG 538 133550-18-2 Tyrosine Kinase/Adaptors IGF-1R AG-538 AG 538 AG538 Tyrphostin AG538 Tyrphostin AG-538 Inhibitor inhibitor inhibit