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Citicoline

Name: Citicoline
Brand: TargetMol
SKU: T0136
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T0136Cas号 987-78-0

别名 尼古林, cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-Choline

Citicoline (CDP-Choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。

Citicoline

一键复制产品信息

很棒

纯度: 99.84%

货号 T0136 别名 尼古林, cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-CholineCas号 987-78-0

Citicoline (CDP-Choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。

规格	价格	库存
10 mg	¥ 129	现货
25 mg	¥ 189	现货
50 mg	¥ 273	现货
100 mg	¥ 379	现货
500 mg	¥ 872	现货
1 g	¥ 1,280	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.84%

颜色: 白色

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COA HPLC HNMR 产品操作手册

产品介绍

Citicoline AI Summary

Citicoline is a diverse bioactive molecule with several notable pharmacological activities. It acts as an inhibitor of Pin1, a regulator of G protein signaling 4 (RGS4), and an enhancer of Arylsulfatase A (ASA1), with potency values ranging from 58.0 nM to 30,131.3 nM across different assays. It has demonstrated neuroprotective effects in primary cortical neurons of Sprague-Dawley rats by reversing oxygen-glucose deprivation-induced neuronal damage at concentrations of 10 µM, 100 µM, and 250 µM, showing activity levels between 53.2% and 87.4% relative to the control. Additionally, Citicoline inhibits sodium fluorescein uptake by 69.94% and 81.06% in OATP1B3 and OATP1B1 transfected CHO cells, respectively. In antiviral contexts, the compound exhibited inhibitory activity against SARS-CoV-2 induced cytotoxicity in Caco-2 cells, although the inhibition was minimal at -1.92% at 10 µM after 48 hours. Its SARS-CoV-2 3CL-Pro protease inhibition was 2.2% at 20 µM. In VERO-6 cells, the inhibition of SARS-CoV-2 induced cytotoxicity was -0.07%. Citicoline was also evaluated for its effects on human HDAC6, showing 6.37% inhibition with a commercial peptide substrate, but -5.67% with a custom substrate. Despite binding to various human and rodent receptors, its significance in ligand-binding assays remains low with AC50 values exceeding 30,000.0 nM, indicating weak affinity. Finally, it showed no significant activity predictive of Drug Induced Liver Injury (DILI) according to the DILIps validation dataset, scoring 0.0 in both O'Brien and Pfizer data..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Citicoline (CDP-Choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
别名	尼古林, cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-Choline

化学信息

分子量	488.32
分子式	C₁₄H₂₆N₄O₁₁P₂
CAS No.	987-78-0
Smiles	O[C@H]1[C@@H](O[C@H](COP(OP(OCC[N+](C)(C)C)(=O)[O-])(=O)O)[C@H]1O)N2C(=O)N=C(N)C=C2
密度	no data available

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 85 mg/mL (174.07 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0478 mL	10.2392 mL	20.4784 mL	102.3919 mL
5 mM	0.4096 mL	2.0478 mL	4.0957 mL	20.4784 mL
10 mM	0.2048 mL	1.0239 mL	2.0478 mL	10.2392 mL
20 mM	0.1024 mL	0.5120 mL	1.0239 mL	5.1196 mL
50 mM	0.0410 mL	0.2048 mL	0.4096 mL	2.0478 mL
100 mM	0.0205 mL	0.1024 mL	0.2048 mL	1.0239 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit EndogenousMetabolite Endogenous Metabolite DopamineReceptor Dopamine Receptor Dopamine Citicoline Apoptosis

Citicoline

Citicoline

Citicoline 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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