Naproxen etemesil

Name: Naproxen etemesil
Brand: TargetMol
SKU: T16272
Rating: 4.5 (1 reviews)

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产品编号 T16272Cas号 385800-16-8

别名 MX 1094, LT-NS 001

Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.

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Naproxen etemesil

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产品编号 T16272 别名 MX 1094, LT-NS 001Cas号 385800-16-8

规格	价格	库存
2 mg	¥ 1,170	5日内发货
5 mg	¥ 1,980	5日内发货
25 mg	¥ 8,620	6-8周
50 mg	¥ 11,200	6-8周
100 mg	¥ 16,200	6-8周
1 mL x 10 mM (in DMSO)	¥ 2,280	5日内发货

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产品介绍

生物活性

产品描述	Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
靶点活性	COX-2:5.15 μM, COX-1:8.72 μM
体外活性	Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1].
体内活性	Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3].
别名	MX 1094, LT-NS 001