Name: Naproxen etemesil
Brand: TargetMol
SKU: T16272
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

2 mg

¥ 1,170

5日内发货

5 mg

¥ 1,980

5日内发货

25 mg

¥ 8,620

6-8周

50 mg

¥ 11,200

6-8周

100 mg

¥ 16,200

6-8周

1 mL x 10 mM (in DMSO)

¥ 2,280

5日内发货

生物活性

产品描述	Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
靶点活性	COX-1:8.72 μM, COX-2:5.15 μM
体外活性	Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1].
体内活性	Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3].
别名	MX 1094, LT-NS 001