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Chrysin

Name: Chrysin
Brand: TargetMol
SKU: T2837
Price: 333 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.75%

货号 T2837Cas号 480-40-0

别名 白杨素, NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone

Chrysin (5,7-Dihydroxyflavone) 是一种雌激素阻断剂。

Chrysin

一键复制产品信息

很棒

纯度: 99.75%

货号 T2837 别名 白杨素, NSC 407436, 5,7-Dihydroxyflavone, 5, 7-DihydroxyflavoneCas号 480-40-0

Chrysin (5,7-Dihydroxyflavone) 是一种雌激素阻断剂。

规格	价格	库存
500 mg	¥ 333	现货
1 g	¥ 418	现货
1 mL x 10 mM (in DMSO)	¥ 418	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.75%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

生物活性

产品描述	Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
别名	白杨素, NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone

化学信息

分子量	254.24
分子式	C₁₅H₁₀O₄
CAS No.	480-40-0
Smiles	OC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1
密度	1.2693 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 130 mg/mL (511.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9333 mL	19.6665 mL	39.3329 mL	196.6646 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL	39.3329 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL	19.6665 mL
20 mM	0.1967 mL	0.9833 mL	1.9666 mL	9.8332 mL
50 mM	0.0787 mL	0.3933 mL	0.7867 mL	3.9333 mL
100 mM	0.0393 mL	0.1967 mL	0.3933 mL	1.9666 mL

TCMIP相关数据

中药材来源及性味归经

中药材名称	中药材拉丁名	性	味	归经
滇黄芩	Scutellaria amoena G.H.Wrignt	寒	苦	肺, 心, 肝, 胆, 大肠

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Chrysin exhibits a multifaceted bioactivity profile, demonstrating potential in various therapeutic and research applications. It acts as an in vitro inhibitor of human gastric adenocarcinoma SGC-7901 and colorectal adenocarcinoma HT-29 cell lines, with IC50 values of 5800.0 nM and 3100.0 nM, respectively, suggesting its potential as an anti-cancer agent. In vivo, it shows hypoglycemic activity in mice at 45 mg/kg, reducing blood glucose levels, and has a significant therapeutic index against H9 cells in HIV1 infection, with EC50 of 5.0 µg/mL and a therapeutic index of 9.0, indicating favorable safety margins. The compound inhibits various enzymes, including aldose reductase (IC50 of 8500.0 nM), xanthine oxidase (IC50 of 840.0 nM), and recombinant human carbonic anhydrases with Ki values between 2650.0 nM to 9070.0 nM. Additionally, it shows antioxidant properties by inhibiting ROS production in bone marrow cells (IC25 of 4480.0 µM). In enzymatic inhibition, Chrysin targets CYP1A1, CYP1A2, and CYP1B1 cytochrome P450 enzymes with IC50 values of 153.0 nM, 84.0 nM, and 24.0 nM, respectively. It also inhibits PIM1 kinase with an IC50 of -1.18 µM and COX2 with significant inhibition of 74.0% at 100 uM. Antibacterial activity is noted, with moderate efficacy against strains like Staphylococcus aureus (MIC of 25.0 - 50.0 µg/mL). The compound exhibits an affinity towards various receptors, including the benzodiazepine site of GABA_A (Ki of 920.0 nM) and PPAR receptors showing agonist activity with notable fold changes at varying concentrations. It also demonstrates interactions with p-glycoprotein, affecting daunomycin accumulation due to hydrophobic properties (logP value of 5.7). In antiviral assays, Chrysin shows activity against HIV1 and Chikungunya virus with IC50 values of 5000.0 nM and 22500.0 nM, respectively. It also exhibits selectivity against Trypanosoma cruzi trans-sialidase and moderate effectiveness against influenza neuraminidase. Overall, Chrysin shows significant potential in multiple applications due to its diverse bioactivities, including anti-cancer, hypoglycemic, antiviral, antibacterial, and enzyme inhibition properties..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl