Moroxydine hydrochloride

Name: Moroxydine hydrochloride
Brand: TargetMol
SKU: T0090
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.15%

货号 T0090Cas号 3160-91-6

别名 盐酸吗啉胍, 病毒灵, Moroxydine HCl, ABOB hydrochloride

Moroxydine hydrochloride (ABOB hydrochloride) 是一种合成的杂环双胍类抗病毒药物。它具有抗病毒活性，有助于预防和治疗流感。

Moroxydine hydrochloride

一键复制产品信息

很棒

纯度: 99.15%

货号 T0090 别名 盐酸吗啉胍, 病毒灵, Moroxydine HCl, ABOB hydrochlorideCas号 3160-91-6

Moroxydine hydrochloride (ABOB hydrochloride) 是一种合成的杂环双胍类抗病毒药物。它具有抗病毒活性，有助于预防和治疗流感。

规格	价格	库存
500 mg	¥ 123	现货
1 g	¥ 153	现货
2 g	¥ 225	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.15%

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COA HNMR LCMS 产品操作手册

产品介绍

Moroxydine hydrochloride AI Summary

Moroxydine hydrochloride has demonstrated various bioactivities in different biological contexts. It shows a potency of 9285.0 nM as an inhibitor of delayed death in the malarial parasite plastid. In SW480 colon adenocarcinoma cells, it induces DNA re-replication with a potency of 794.3 nM. It also acts as a TDP-43 inhibitor with a potency of 28183.8 nM. In the context of Ebola Virus entry inhibition, Moroxydine hydrochloride has an AC50 of 1.413 μM in the blue channel and 0.631 μM in the ratio channel. Regarding its antiviral properties, Moroxydine hydrochloride exhibits activity against SARS-CoV-2. Specifically, it shows low-level inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 strain BavPat1, with an inhibition index of 0.171. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by -6.4% at a 10 μM concentration after 48 hours, and it shows 11.42% inhibition of SARS-CoV-2 3CL-Pro protease at a 20 μM concentration. Additionally, it demonstrates -0.02% inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells under similar conditions. Furthermore, Moroxydine hydrochloride exhibits high solubility at pH 8, with a value of 360000.0 μg/mL. It also shows a binding affinity to SARS-CoV-2 3CL protease, with a Gibbs free energy change of -2.11 kcal/mol, indicating its potential as a protease inhibitor in the treatment of SARS-CoV-2 infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. It has antiviral activity and is helpful in the prevention and treatment of influenza.
别名	盐酸吗啉胍, 病毒灵, Moroxydine HCl, ABOB hydrochloride

化学信息

分子量	207.66
分子式	C₆H₁₃N₅O·HCl
CAS No.	3160-91-6
Smiles	Cl.NC(=N)NC(=N)N1CCOCC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (240.78 mM), Sonication is recommended.

H2O: 202.3 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.63 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8156 mL	24.0778 mL	48.1556 mL	240.7782 mL
5 mM	0.9631 mL	4.8156 mL	9.6311 mL	48.1556 mL
10 mM	0.4816 mL	2.4078 mL	4.8156 mL	24.0778 mL
20 mM	0.2408 mL	1.2039 mL	2.4078 mL	12.0389 mL
50 mM	0.0963 mL	0.4816 mL	0.9631 mL	4.8156 mL
100 mM	0.0482 mL	0.2408 mL	0.4816 mL	2.4078 mL