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NS-1619

Name: NS-1619
Brand: TargetMol
SKU: T3102
Price: 283 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T3102Cas号 153587-01-0 一键复制产品信息纯度: 98%

很棒

NS 1619 是 Ca2+激活的 K+(BK) 通道的激活剂，是一种高效的松弛剂，在血管和其他组织的几个平滑肌中的 EC50约为 10 – 30 μM。它抑制A2780卵巢癌细胞增殖并诱导细胞凋亡。

NS-1619

一键复制产品信息

很棒

纯度: 98%

货号 T3102Cas号 153587-01-0

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 283	现货
2 mg	¥ 395	现货
5 mg	¥ 663	现货
10 mg	¥ 828	现货
25 mg	¥ 1,390	现货
50 mg	¥ 1,930	现货
100 mg	¥ 2,970	现货
1 mL x 10 mM (in DMSO)	¥ 728	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.66%

颜色: 白色

资源下载: COA HNMR LCMS HPLC产品操作手册

产品介绍

NS-1619 AI Summary

NS-1619 demonstrates a wide range of bioactivities across various biological systems and assays. It acts as an activator of maxi-K (BK) channels expressed in Xenopus laevis oocytes and CHO-K1 cells, showing significant increases in channel opening at concentrations of 20 uM and 30 uM, respectively. This includes a notable 325.2% relative increase in ionic current in CHO-K1 cells and a 116.0% increase in outward current in Xenopus laevis oocytes. The compound also induces BK channel-mediated vasorelaxation in KCl-induced contraction in Wistar rat aorta, with an Emax of up to 94.0% and IC50 values ranging from 4365.16 nM to 5888.44 nM. Additionally, NS-1619 exhibits protective effects against Bacillus anthracis lethal toxin in mouse RAW264.7 cells, increasing cell viability by 2.8-fold compared to controls. It has antiplasmodial activity against Plasmodium falciparum strains and demonstrates binding affinity to the Hsp90alpha N-terminal ATPase domain with an IC50 of 3320 nM. The compound also exhibits high plasma protein binding activity in mouse, human, and rat plasma samples, with PPB values exceeding 99.79%. Collectively, these findings highlight NS-1619's potential therapeutic applications in various disease pathways and cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NS1619 have cardio-protective effects after ischemia-reperfusion injury.
靶点活性	BKCa channel:32 microM(ec50)

化学信息

分子量	362.23
分子式	C₁₅H₈F₆N₂O₂
CAS No.	153587-01-0
Smiles	Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
密度	1.563 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (138.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7607 mL	13.8034 mL	27.6068 mL	138.0338 mL
5 mM	0.5521 mL	2.7607 mL	5.5214 mL	27.6068 mL
10 mM	0.2761 mL	1.3803 mL	2.7607 mL	13.8034 mL
20 mM	0.1380 mL	0.6902 mL	1.3803 mL	6.9017 mL
50 mM	0.0552 mL	0.2761 mL	0.5521 mL	2.7607 mL
100 mM	0.0276 mL	0.1380 mL	0.2761 mL	1.3803 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。