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信号通路 / 研究领域
为众多的药物研发团队赋能, 让新药发现更简单
肿瘤/癌症
肿瘤是一种由身体内的细胞失去正常生长控制而无限制地增生所致的一种严重疾病，可以发生在身体的任何部位，如肺、乳腺、结肠和皮肤等。癌症是全球健康的主要威胁之一，每年导致数百万人死亡，给患者及其家庭带来深重的痛苦和经济负担。近年来，癌症治疗领域取得了显著进展，尤其是在靶向疗法和免疫疗法等方面。研究者正在努力发现新的生物标志物和治疗方法，以进一步提高治疗效果。
免疫和炎症疾病
免疫和炎症疾病构成了一系列多样且复杂的健康问题，主要涉及免疫系统的异常反应。这类疾病包括类风湿性关节炎和系统性红斑狼疮等自身免疫疾病，以及哮喘和过敏性疾病等由于免疫系统对环境因素的过度反应所引起的病状。这些疾病的复杂性源于其发病机制，涉及遗传因素、环境影响以及生活方式等多重因素，它们不仅对个体健康构成挑战，也对公共卫生系统带来了重大负担。近年来，医学研究领域关注于解析和调节免疫系统的机制，以发展出更有效的治疗方法，包括精确调控免疫反应、开发针对特定免疫通路的创新药物，以及探索新的炎症反应缓解策略等。
神经退行性疾病
神经退行性疾病是一类影响神经系统的疾病，主要特征是神经细胞的逐渐退化和死亡。这类疾病包括阿尔茨海默病、帕金森病、亨廷顿病等，它们通常导致认知功能下降、运动能力受损以及其他神经功能障碍。随着全球人口老龄化，这些疾病的发病率正在逐渐上升，对患者及其家庭构成重大挑战。神经退行性疾病的确切原因仍然是科学研究的重点。目前认为，遗传因素、环境因素以及生活方式等都可能对这类疾病的发展有影响。由于这些疾病的症状和进展方式各不相同，因此对它们的研究和治疗也呈现出高度的复杂性。
内分泌和代谢疾病
内分泌和代谢疾病，如糖尿病、甲状腺功能紊乱、肾上腺疾病和肥胖症等，是由内分泌腺功能异常或代谢过程的紊乱引起的。内分泌系统，包括甲状腺、胰腺和肾上腺等，通过分泌激素来调控人体众多生理功能。这些激素直接影响身体的代谢过程，如物质的合成和分解。当这一平衡受到干扰时，可能导致能量代谢的异常，从而严重影响患者的日常生活和健康。近年来，研究的重点集中在开发针对这些疾病的新型治疗药物、优化现有的激素替代疗法，以及深入理解遗传和生活方式因素对这些疾病的影响。目标是提高治疗效果，减少药物副作用，并提升患者的生活质量。
心血管疾病
心血管疾病是指影响心脏和血管系统的一系列疾病，包括冠状动脉疾病（导致心绞痛和心肌梗死）、高血压、心力衰竭、脑血管疾病等。这些疾病通常与血管健康受损密切相关，例如动脉硬化，同时生活方式因素，如不健康饮食、缺乏运动、吸烟和过度饮酒等也是主要的因素。心血管疾病是全球主要的健康问题之一，是成年人死亡的主要原因之一。预防和治疗心血管疾病不仅需要关注生活方式的改变，药物治疗和手术干预也发挥着关键作用。研究者们致力于解析心血管疾病的发病机制，并开发和测试新的药物和治疗策略，以更有效地应对这类疾病的挑战。
传染病
传染病是由各种病原体（如细菌、病毒、真菌或寄生虫）引起的疾病，它们可能通过空气、食物、水或直接的人际接触等多种途径传播。常见的传染病包括流感、HIV/AIDS、结核病、疟疾和新型冠状病毒疾病等。这些疾病对全球公共卫生构成严重的威胁。在防治传染病的过程中，疫苗的开发、有效的抗生素和抗病毒药物的使用等扮演着重要的角色。为应对抗生素耐药性的不断增加和新兴传染病的挑战，新型小分子药物开发是战胜这些全球性健康威胁的重要策略。
类器官与干细胞
类器官（Organoids）是一种在实验室环境下培养的三维微型组织结构，能够模拟真实器官的细胞构成、结构和功能，已成为现代生物医学研究的重要工具。在构建疾病模型、药物筛选和毒性测试等方面发挥着关键作用。类器官通常来源于干细胞，在特定的培养条件下，干细胞能够分化成多种细胞类型，进而组合形成类器官。干细胞作为这一过程的核心，具有显著的自我更新能力和向各种细胞类型分化的潜能。
化合物库
我们可以提供800多种不同类型、结构、来源和规模的小分子化合物库，用于新药发现的高通量筛选，帮助药物开发人员发现有前景的化合物。
2025,188(7):1858-1877.e21.Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response
2025,188(4):944-957.e19.Squeeze pumping of lipids and insecticides by ABCH transporter
2025,37(4):857-869.e9.Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
2025,37(2):514-526.e5.Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1
2025,37(1):291-304.e9.Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
2025,35(1):59-71.LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
2024,187(13):3409-3426.e24.Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
2024,632(8024):419-428.In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution
2024, 627(8002):149-156.Multisensory gamma stimulation promotes glymphatic clearance of amyloid
2024,628(8006):E1.An atlas of epithelial cell states and plasticity in lung adenocarcinoma
2024,23(1):1-27.A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway
2024,57(10):2344-2361.e7.Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
2024,81(4):651-666.Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
2024,36(11):2402-2418.e10.Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
2024,36(9):2086-2103.e9.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response
2024,25(11):2057-2067.GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity
文献引用
2025,188(7):1858-1877.e21.
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response2025,188(4):944-957.e19.
Squeeze pumping of lipids and insecticides by ABCH transporter2025,37(4):857-869.e9.
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST2025,37(2):514-526.e5.
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L12025,37(1):291-304.e9.
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology2025,35(1):59-71.
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer2024,187(13):3409-3426.e24.
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor2024,632(8024):419-428.
In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution2024, 627(8002):149-156.
Multisensory gamma stimulation promotes glymphatic clearance of amyloid2024,628(8006):E1.
An atlas of epithelial cell states and plasticity in lung adenocarcinoma2024,23(1):1-27.
A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway2024,57(10):2344-2361.e7.
Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation2024,81(4):651-666.
Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD2024,36(11):2402-2418.e10.
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury2024,36(9):2086-2103.e9.
TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response2024,25(11):2057-2067.
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity
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大咖说
我课题组在十多年前刚成立时便通过TargetMol采购了一套小分子化合物库，这为我们的高通量筛选实验提供了很好的支持。至今，我们一直保持良好的合作关系，TargetMol的化合物种类多、纯度高、质量好，交货及时且包装精美。每次合作，TargetMol的工作人员都非常专业，能够快速响应我们的需求。总体来说，TargetMol提供的产品和服务一直令我们非常满意，是我们信赖的长期合作伙伴。大咖说
在和TargetMol的项目合作中，30克重要化合物的定制合成完成的非常好，值得称赞。首先，TargetMol的报价是非常有竞争力的，在项目启动之前，我们先要求提供了小样，寄的小样化合物的核磁、质谱、高效液相色谱、恒重实验都检验合格，双方确定了交付标准并以此标准来执行；其次，在项目执行过程中，TargetMol和我们保持了顺畅的交流和沟通，做到了每周的及时进展更新，对于我们指出的问题也能及时反馈和解决；第三，TargetMol的样品包装做到了规范、专业、精美，打开样品盒子看着很舒服。总之，在双方的顺畅交流合作下，TargetMol为我们提供了一次物美价廉的化合物定制合成服务，感谢TargetMol。What Our Customer Says
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