Tubulin inhibitor 24

Name: Tubulin inhibitor 24
Brand: TargetMol
SKU: T9812
Price: 780 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.99%

货号 T9812Cas号 2415761-65-6

Tubulin inhibitor 24 是一种 tubulin 抑制剂，可以抑制微管蛋白聚合，以浓度依赖性方式诱导细胞周期停滞在 G2/M 期，具有抗肿瘤活性且无明显毒性。

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Tubulin inhibitor 24

一键复制产品信息

很棒

纯度: 99.99%

货号 T9812Cas号 2415761-65-6

Tubulin inhibitor 24 是一种 tubulin 抑制剂，可以抑制微管蛋白聚合，以浓度依赖性方式诱导细胞周期停滞在 G2/M 期，具有抗肿瘤活性且无明显毒性。

规格	价格	库存
1 mg	¥ 780	现货
5 mg	¥ 1,750	现货
10 mg	¥ 2,590	现货
25 mg	¥ 4,120	现货
50 mg	¥ 5,590	现货
100 mg	¥ 7,500	现货
500 mg	¥ 15,100	现货

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产品介绍

Tubulin inhibitor 24 AI Summary

Tubulin inhibitor 24 exhibits potent antiproliferative activity against various human cancer cell lines, including HeLa, MCF7, A549, and HCT-116, as well as mouse B16-F0 cells, with IC50 values ranging from 3.0 nM to 48.0 nM. It inhibits pig brain tubulin polymerization with an IC50 of 2100.0 nM and demonstrates binding affinity to pig brain tubulin under various temperatures and preincubation conditions. Additionally, the compound shows good metabolic stability in human and mouse liver microsomes, with half-lives of approximately 2 hours. In terms of antitumour activity, Tubulin inhibitor 24 significantly reduces tumour weight and volume in mice transplanted with B16-F0 cells, with activity percentages ranging from 38.6% to 77.4% at different doses..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.

化学信息

分子量	375.42
分子式	C₂₂H₂₁N₃O₃
CAS No.	2415761-65-6
Smiles	O(C)C=1C=C(C=2N3C(=CC(=N3)C4=CC=C(C)C=C4)N=CC2)C=C(OC)C1OC
密度	1.21 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 11 mg/mL (29.3 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6637 mL	13.3184 mL	26.6368 mL	133.1842 mL
5 mM	0.5327 mL	2.6637 mL	5.3274 mL	26.6368 mL
10 mM	0.2664 mL	1.3318 mL	2.6637 mL	13.3184 mL
20 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6592 mL