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Benoxaprofen

Name: Benoxaprofen
Brand: TargetMol
SKU: T19679
Price: 1990 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氧苯恶唑丙酸, NSC 299582, LY-90459, Benoxaphen. Compound 90459

货号 T19679Cas号 51234-28-7 一键复制产品信息纯度: 98.87%

很棒

Benoxaprofen (NSC-299582) 是长效的、强效的抗炎和解热化合物，在体外具有较弱的对环氧合酶的抑制作用，也可以抑制脂氧合酶，在一些炎症动物模型中抑制单核细胞迁移。

Benoxaprofen

一键复制产品信息

很棒

纯度: 98.87%

货号 T19679Cas号 51234-28-7

别名 氧苯恶唑丙酸, NSC 299582, LY-90459, Benoxaphen. Compound 90459

规格	价格	库存
1 mg	¥ 1,990	现货
5 mg	¥ 4,720	现货
10 mg	¥ 6,590	现货
25 mg	¥ 9,780	现货
50 mg	¥ 12,900	现货
100 mg	¥ 17,700	现货
1 mL x 10 mM (in DMSO)	¥ 4,770	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.87%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Benoxaprofen AI Summary

Benoxaprofen demonstrates significant anti-inflammatory activity in both acute and subchronic inflammation models, with an ED50 of 15.0 mg/kg and an ED40 of 10.0 mg/kg, respectively. It shows good gastrointestinal tolerability in acute conditions with an ulcerogenic dose (UD) of over 200.0 mg/kg but has a much lower UD in chronic conditions, under 30.0 mg/kg. Safety assessments reveal minimal blood loss at doses less than 50.0 mg/kg and low lethality in rats at doses below 50.0 mg/kg. The compound has a pKa value of 6.9, suggesting varying levels of ionization at different pH conditions, and a high plasma protein binding activity of 99.76% with a LogD7.4 value of 1.3. It also exhibits specific activity in the UGT2B7 enzyme and shows inhibition of rat Bsep and human BSEP with IC50 values of 99100.0 nM and 175000.0 nM, respectively. Benoxaprofen also affects liver and kidney function, changing various biochemical parameters such as ALT, AST, ALP, BILI, BUN, CREAT, RBC, WBC, PLAT, CHLORIDE, SODIUM, POTASSIUM, ALB, and PROT. The compound has been evaluated in DILIps datasets, showing a DILI score of 1.0, suggesting potential drug-induced liver injury. It has an LD50 of 800.0 mg/kg when administered orally and a terminal half-life of 19.0 hours in humans. Additionally, it demonstrates antiviral activity against SARS-CoV-2 with an IC50 greater than 20000.0 nM and inhibits human BSEP with an IC50 of 103700.0 nM. Benoxaprofen affects drug metabolism in human Hep3B cells, impacting CYP3A4, CYP2D6, and CYP2C9 activities, and shows binding affinities towards various receptors and transporters, including human MAOA and CCKBR..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.
别名	氧苯恶唑丙酸, NSC 299582, LY-90459, Benoxaphen. Compound 90459

化学信息

分子量	301.72
分子式	C₁₆H₁₂ClNO₃
CAS No.	51234-28-7
Smiles	C(C(O)=O)(C)C=1C=C2C(OC(=N2)C3=CC=C(Cl)C=C3)=CC1
密度	1.2411 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (198.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3143 mL	16.5717 mL	33.1433 mL	165.7166 mL
5 mM	0.6629 mL	3.3143 mL	6.6287 mL	33.1433 mL
10 mM	0.3314 mL	1.6572 mL	3.3143 mL	16.5717 mL
20 mM	0.1657 mL	0.8286 mL	1.6572 mL	8.2858 mL
50 mM	0.0663 mL	0.3314 mL	0.6629 mL	3.3143 mL
100 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6572 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。