Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 819 | 5日内发货 | ||
25 mg | ¥ 5,970 | 6-8周 | ||
50 mg | ¥ 7,920 | 6-8周 |
产品描述 | TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2]. |
靶点活性 | TRPM4:0.16 μM |
体外活性 | TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.[1] |
别名 | NBA |
分子量 | 355.77 |
分子式 | C19H14ClNO4 |
CAS No. | 667411-04-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (253.0 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8108 mL | 14.054 mL | 28.108 mL | 70.2701 mL |
5 mM | 0.5622 mL | 2.8108 mL | 5.6216 mL | 14.054 mL | |
10 mM | 0.2811 mL | 1.4054 mL | 2.8108 mL | 7.027 mL | |
20 mM | 0.1405 mL | 0.7027 mL | 1.4054 mL | 3.5135 mL | |
50 mM | 0.0562 mL | 0.2811 mL | 0.5622 mL | 1.4054 mL | |
100 mM | 0.0281 mL | 0.1405 mL | 0.2811 mL | 0.7027 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TRPM4-IN-2 667411-04-3 Membrane transporter/Ion channel TRP/TRPV Channel NBA Inhibitor inhibitor inhibit