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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Diphenylpyraline hydrochloride

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纯度: 98.72%

货号 T0059Cas号 132-18-3

别名 盐酸双苯比拉林, 4-Diphenylmethoxy-1-methylpiperidine hydrochloride

Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂，抑制多巴胺的吸收。它是可口服的抗组胺试剂，具有抗胆碱和抗过敏作用，可用于缓解过敏性疾病，如鼻炎、花粉热和瘙痒性皮肤疾病等。

Diphenylpyraline hydrochloride
其他形式的 “Diphenylpyraline hydrochloride”:
DiphenylpyralineT0059L147-20-6
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Diphenylpyraline hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 98.72%

货号 T0059 别名 盐酸双苯比拉林, 4-Diphenylmethoxy-1-methylpiperidine hydrochlorideCas号 132-18-3

Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂，抑制多巴胺的吸收。它是可口服的抗组胺试剂，具有抗胆碱和抗过敏作用，可用于缓解过敏性疾病，如鼻炎、花粉热和瘙痒性皮肤疾病等。

规格价格库存数量
500 mg
¥ 123
现货
1 mL x 10 mM (in DMSO)
¥ 250
现货
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产品介绍

Diphenylpyraline hydrochloride AI Summary
Diphenylpyraline hydrochloride exhibits a multifaceted bioactivity profile. It demonstrates antimicrobial activity against Mycobacterium tuberculosis H37Rv with an inhibition rate of 5.0% at 6.25 µg/mL and an MIC of 64.0 µg/mL. Additionally, it exhibits cytotoxicity against HEK293 cells with an LC50 value of 107.59 µg/mL. The compound shows inhibition of several key biological targets: 1. Inhibition of IMPase with a potency of 2238.7 nM. 2. Moderate inhibition of the ERK signaling pathway with a potency of 39810.7 nM. 3. Inhibition of AmpC Beta-Lactamase and Histone Lysine Methyltransferase G9a, both with a potency of 89125.1 nM. 4. Inhibition of the malarial parasite plastid with a potency of 18526.0 nM. 5. Inhibition of viral entry mechanisms for Lassa Virus, Marburg Virus, and Ebola Virus with potencies ranging from 12589.3 nM to 3548.1 nM. 6. Activity in a cell-based assay for B-Galactocerebrosidase with a potency of 707.9 nM. Furthermore, Diphenylpyraline hydrochloride significantly inhibits OATP1B3 and OATP1B1 transporters with 87.39% and 68.46% inhibition at 10 µM, respectively. It also demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells and VERO-6 cells at 10 µM, with inhibition rates of 13.81% and -0.01% respectively, and by inhibiting the SARS-CoV-2 3CL-Pro protease by 23.7% at 20 µM. Diphenylpyraline hydrochloride, however, shows lower activity against SARS-CoV-2-induced cytotoxicity in Vero E6 cells compared to the arbidol control, with an inhibition index of 0.8198. Overall, Diphenylpyraline hydrochloride is a versatile bioactive compound with potential applications in antimicrobial and antiviral therapies, as well as in modulating various cellular pathways..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reuptake inhibitor.
别名盐酸双苯比拉林, 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
化学信息
分子量317.85
分子式C19H23NO·HCl
CAS No.132-18-3
SmilesCl.CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 55 mg/mL (173.04 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.29 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.1461 mL15.7307 mL31.4614 mL157.3069 mL
5 mM0.6292 mL3.1461 mL6.2923 mL31.4614 mL
10 mM0.3146 mL1.5731 mL3.1461 mL15.7307 mL
20 mM0.1573 mL0.7865 mL1.5731 mL7.8653 mL
50 mM0.0629 mL0.3146 mL0.6292 mL3.1461 mL
100 mM0.0315 mL0.1573 mL0.3146 mL1.5731 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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