规格

价格

库存

数量

2 mg

¥ 468

5日内发货

5 mg

¥ 858

5日内发货

100 mg

¥ 7,960

5日内发货

生物活性

产品描述	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
靶点活性	FGFR:9 nM, VEGFR2:11 nM
体外活性	CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion (IC50: 6 nM).
体内活性	In DLD-1, Colo-205, and MDA-MB-231 xenografts, CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth. CP-547632 hydrochloride (oral; 50 mg/kg) yields plasma concentrations above 500 ng/ml for 12 hours.

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 38.33 mg/mL (67.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.52 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO