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Vatalanib free base

Name: Vatalanib free base
Brand: TargetMol
SKU: T17219
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 瓦他拉尼碱

货号 T17219Cas号 212141-54-3 一键复制产品信息纯度: 99.52%

很棒

Vatalanib free base 是一种 VEGFR2/KDR 的抑制剂，其IC50=37nM。

Vatalanib free base

一键复制产品信息

很棒

纯度: 99.52%

货号 T17219Cas号 212141-54-3

别名 瓦他拉尼碱

Vatalanib free base 是一种 VEGFR2/KDR 的抑制剂，其IC50=37nM。

规格	价格	库存
1 mg	¥ 153	现货
2 mg	¥ 208	现货
5 mg	¥ 328	现货
10 mg	¥ 529	现货
25 mg	¥ 959	现货
50 mg	¥ 1,520	现货
100 mg	¥ 2,250	现货
500 mg	¥ 5,370	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.52%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Vatalanib free base AI Summary

Vatalanib free base exhibits significant bioactivity primarily as an inhibitor of Vascular Endothelial Growth Factor Receptors (VEGFRs). It shows potent inhibition of VEGFR2 in various assays, with IC50 values ranging from 21.0 nM to 54.0 nM, and a strong affinity for VEGFR2 in cell-based studies, demonstrating an IC50 of 21.0 nM in HEK293 cells. Additionally, it inhibits VEGFR1 with IC50 values typically around 140.0 nM. The compound also affects the phosphorylation of VEGF receptors, blocking their activation in cell-based assays. Moreover, Vatalanib free base inhibits other kinases, though with lesser potency, such as Proto-oncogene tyrosine-protein kinase Kit (IC50 = 700.0 nM) and others like PDGFRB and FLT4 with binding affinities (Kd) of 58.0 nM and 190.0 nM respectively. Despite these broader interactions, it's particularly noted for its selectivity towards VEGFR2, indicating its potential as a therapeutic agent for conditions involving VEGF signaling. In vivo studies showed inhibitory activity on tumor growth and antiangiogenic effects, such as inhibition of VEGF-induced proliferation of human umbilical vein endothelial cells (IC50 = 33.0 nM) and in zebrafish models showing antiangiogenic activity with an IC50 of 230.0 nM. Additionally, it manifests anti-inflammatory properties by inhibiting paw edema in a rat arthritis model. The compound also demonstrates weak cytotoxicity against various cancer cell lines (A549, HT-29, MDA-MB-231) with IC50 values greater than 20000.0 nM, and limited antiviral and HDAC6 inhibitory activities, indicating a broad but varied bioactivity profile. Vatalanib free base's diverse inhibitory effects on multiple signaling pathways underscore its potential for further therapeutic investigations, particularly its strong inhibition of VEGFR2 signaling..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM).
靶点活性	VEGFR2:37 nM (IC50)
别名	瓦他拉尼碱

化学信息

分子量	346.81
分子式	C₂₀H₁₅ClN₄
CAS No.	212141-54-3
Smiles	ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C3=CC=CC=C23)C=C1
密度	1.330 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 122 mg/mL (351.78 mM), Sonication and heating are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8834 mL	14.4171 mL	28.8342 mL	144.1712 mL
5 mM	0.5767 mL	2.8834 mL	5.7668 mL	28.8342 mL
10 mM	0.2883 mL	1.4417 mL	2.8834 mL	14.4171 mL
20 mM	0.1442 mL	0.7209 mL	1.4417 mL	7.2086 mL
50 mM	0.0577 mL	0.2883 mL	0.5767 mL	2.8834 mL
100 mM	0.0288 mL	0.1442 mL	0.2883 mL	1.4417 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

ZK-222584 ZK222584 ZK 222584 VEGFR2 VEGFR Vatalanib free base Vatalanib Vascular endothelial growth factor receptor PTK-787 PTK787 PTK/ZK PTK 787 Inhibitor inhibit CGP-79787 CGP79787 CGP 79787

Vatalanib free base

Vatalanib free base