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4(3H)-Quinazolinone

Name: 4(3H)-Quinazolinone
Brand: TargetMol
SKU: TMO2713
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.23%

货号 TMO2713Cas号 491-36-1

别名 Quinazolin-4-ol, 4-羟基喹唑啉, 4-Quinazolone, 4-Quinazolinone, 4-Quinazolinol, 4-Hydroxyquinazoline

4(3H)-Quinazolinone (4-Hydroxyquinazoline) 是化学合成中的砌块，是一种生物活性氮杂环化合物。它具有多种生物学特性，如抗菌，抗真菌，抗惊厥，抗炎，抗 HIV，抗癌和缓解疼痛活性。

为众多的药物研发团队赋能，

让新药发现更简单！

4(3H)-Quinazolinone

一键复制产品信息

很棒

纯度: 99.23%

货号 TMO2713 别名 Quinazolin-4-ol, 4-羟基喹唑啉, 4-Quinazolone, 4-Quinazolinone, 4-Quinazolinol, 4-HydroxyquinazolineCas号 491-36-1

规格	价格	库存
50 mg	¥ 129	现货
100 mg	¥ 213	现货
500 mg	¥ 428	现货
1 g	¥ 596	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.23%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

4(3H)-Quinazolinone AI Summary

4(3H)-Quinazolinone demonstrates a spectrum of bioactivities across various targets and assays. It has significant inhibitory effects on poly(ADP-ribose)-polymerase (PARP1), with IC50 values ranging from 5,750.0 nM to 15,800.0 nM, and shows strong inhibition of PARP1 activity (>60.0%). It also inhibits rat liver dihydrofolate reductase (DHFR) with a Log 1/C value of 3.62 and modulates nitric oxide (NO) production in BCG-treated ICR mouse macrophages at an activity level of 29.0%. Additionally, 4(3H)-Quinazolinone binds to Mycobacterium tuberculosis purine nucleoside phosphorylase with a dissociation constant (Kd) of 316,227.77 nM. In terms of enzymatic activity, it inhibits 15-human lipoxygenase (15-hLO) and Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with potencies of 39,810.7 nM and 79,432.8 nM, respectively. It also affects human PDE10A2 with a Ki value of 910,000.0 nM and liver PDK1 with an IC50 value of 345,000.0 nM. 4(3H)-Quinazolinone shows moderate inhibitory activity against carbonic anhydrases 9 and 12 (Ki = 15,700.0 nM and 10,460.0 nM, respectively), and weak inhibition against carbonic anhydrases 1 and 2 (Ki > 500,000.0 nM). It demonstrates bronchodilatory effects in Wistar rat trachea with an ED50 of 0.81 mmol/L and inhibits chronic active B-cell receptor signaling with a potency of 290.9 nM. The compound exhibits substantial antiviral activity against SARS-CoV-2. It inhibits the virus-induced cytotoxicity of Caco-2 cells and VERO-6 cells, with inhibition rates of -10.42% and 0.24% at 10 µM concentration, respectively. It also inhibits SARS-CoV-2 3CL-Pro protease by 37.21% at a concentration of 20 µM. Additionally, it modulates lipid storage in Drosophila S3 cells (730.8 nM) and induces DNA re-replication in SW480 colon adenocarcinoma cells (6513.1 nM). 4(3H)-Quinazolinone's diverse bioactivities indicate its potential for various therapeutic applications. However, further studies are necessary to fully understand its mechanisms and optimize its efficacy..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4(3H)-Quinazolinone (4-Hydroxyquinazoline) is a chemically synthesized masonry block, a biologically active nitrogen heterocyclic compound. It possesses various biological properties such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and pain relieving activities.
别名	Quinazolin-4-ol, 4-羟基喹唑啉, 4-Quinazolone, 4-Quinazolinone, 4-Quinazolinol, 4-Hydroxyquinazoline

化学信息

分子量	146.15
分子式	C₈H₆N₂O
CAS No.	491-36-1
Smiles	OC1=NC=NC2=CC=CC=C12
密度	1.31 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 40 mg/mL (273.69 mM), Sonication is recommended.

H2O: 1.5 mg/mL (10.26 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.68 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8423 mL	34.2114 mL	68.4229 mL	342.1143 mL
5 mM	1.3685 mL	6.8423 mL	13.6846 mL	68.4229 mL
10 mM	0.6842 mL	3.4211 mL	6.8423 mL	34.2114 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.3421 mL	1.7106 mL	3.4211 mL	17.1057 mL
50 mM	0.1368 mL	0.6842 mL	1.3685 mL	6.8423 mL
100 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4211 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Plateletaggregation Platelet aggregation Inhibitor inhibit Bacterial 4(3H)-Quinazolinone 4(3H)Quinazolinone 4(3H) Quinazolinone

4(3H)-Quinazolinone

4(3H)-Quinazolinone