购物车

您的购物车当前为空

Phenylbutazone

Name: Phenylbutazone
Brand: TargetMol
SKU: T1432
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.93%

货号 T1432Cas号 50-33-9

别名 保泰松, Butazolidine

Phenylbutazone (Butazolidine) 是是非甾体类抗炎药，前列腺素 H 合酶过氧化物酶的还原辅助因子，可诱导肌肉盲样蛋白 1 表达，有用于强直性脊柱炎的研究潜力。

Phenylbutazone

一键复制产品信息

很棒

纯度: 99.93%

货号 T1432 别名 保泰松, ButazolidineCas号 50-33-9

规格	价格	库存
50 mg	¥ 137	现货
100 mg	¥ 186	现货
500 mg	¥ 413	现货
1 g	¥ 579	现货
5 g	¥ 1,380	现货
10 g	¥ 1,980	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.93%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Phenylbutazone AI Summary

Phenylbutazone exhibits significant anti-inflammatory activity through multiple mechanisms, including the inhibition of carrageenan-induced paw edema in rats with varying levels of dose-dependent inhibition. The compound demonstrates inhibitory activity against canine COX-2 with an IC50 of 3790.0 nM and oval tissue PGH synthase with an IC50 of 10000.0 nM, as well as binding affinity to cytochrome P450 2C9 with a Ki of 19000.0 nM. The anti-inflammatory effects are evident in both the carrageenan-induced and adjuvant-induced models, with ED50 values ranging from 10.0 mg/kg to 37.5 mg/kg depending on the specific assay. Besides its anti-inflammatory properties, Phenylbutazone has analgesic effects, as shown by reduced writhing in the acetic acid test and increased reaction time in the hot plate test. However, it also poses potential risks, including ulcerogenic effects at higher doses and moderate acute toxicity, with LD50 values reported around 300 mg/kg in mice. The compound possesses a partition coefficient (logP) of 3.04, pKa of 4.4, and notable binding affinity to human serum albumin (log B/F value of 1.619). Additionally, it demonstrates moderate to high activity in displacing other compounds from human serum albumin binding sites. Moreover, Phenylbutazone shows varying inhibitory effects on human liver enzymes UGT1A6 and UGT1A9 and on transporter systems, indicating possible interactions affecting drug metabolism and transport. Despite moderate hepatotoxic risks and demonstrated ulcerogenic activity, the compound's multi-target action profile underscores its potential therapeutic applications, albeit with necessary considerations for dosage and side effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Phenylbutazone (Butazolidine) is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthritis.
别名	保泰松, Butazolidine

化学信息

分子量	308.37
分子式	C₁₉H₂₀N₂O₂
CAS No.	50-33-9
Smiles	CCCCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1
密度	1.173g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (178.36 mM), Sonication is recommended.

Ethanol: 58 mg/mL (188.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.49 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2429 mL	16.2143 mL	32.4286 mL	162.1429 mL
5 mM	0.6486 mL	3.2429 mL	6.4857 mL	32.4286 mL
10 mM	0.3243 mL	1.6214 mL	3.2429 mL	16.2143 mL
20 mM	0.1621 mL	0.8107 mL	1.6214 mL	8.1071 mL
50 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2429 mL
100 mM	0.0324 mL	0.1621 mL	0.3243 mL	1.6214 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

synthase spondylitis prostaglandin PHS Phenylbutazone NSAID MBNL1 Inhibitor inhibit hepatotoxin Cyclooxygenase COX ankylosing

Phenylbutazone

Phenylbutazone

Phenylbutazone 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词