Name: BMT-090605
Brand: TargetMol
SKU: T14691
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 15,000

8-10周

50 mg

¥ 19,800

8-10周

100 mg

¥ 25,500

8-10周

生物活性

产品描述	BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.
体外活性	BMT-090605 shows a cellular IC50 of 0.63 ±0.39 nM for AAK1[1].
体内活性	BMT-090605 (0.3-3 μg/rat; intrathecally at lumbar level L5/L6) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Exposure measurements from this study indicated that brain and plasma levels of BMT-090605 were <4 nM, whereas measurable levels (90–317 nM) were observed in lumbar spinal cord[1]. The high dose of BMT-090605 (3 μg/rat) showed efficacy comparable to intrathecal clonidine (3 μg/rat).

化学信息

分子量	364.44
分子式	C₂₁H₂₄N₄O₂
CAS No.	1551403-51-0
Smiles	CN1C=2C(C=3C(C1=O)=C(C)N=CC3)=CC(C#N)=C(OC[C@H](CC(C)C)N)C2
密度	1.24 g/cm3 (Predicted)