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IKK2-IN-4

Name: IKK2-IN-4
Brand: TargetMol
SKU: T36524
Price: 618 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.83%

货号 T36524Cas号 354811-10-2

别名 IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。

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IKK2-IN-4

一键复制产品信息

很棒

纯度: 99.83%

货号 T36524 别名 IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid AmideCas号 354811-10-2

IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。

规格	价格	库存
500 μg	¥ 618	现货
1 mg	¥ 923	现货
5 mg	¥ 1,710	现货
10 mg	¥ 2,560	现货
25 mg	¥ 4,090	现货
50 mg	¥ 5,520	现货
100 mg	¥ 7,420	现货
200 mg	¥ 10,000	现货

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COA HNMR LCMS 产品操作手册

产品介绍

IKK2-IN-4 AI Summary

IKK2-IN-4 exhibits significant bioactivity as an inhibitor of multiple enzymes, including IKK-beta with an IC50 value of approximately 13.0 nM, JAK2 with an IC50 of 61.0 nM, and JAK3 with an IC50 of 2000.0 nM. It demonstrates potential anti-inflammatory and immune response modulation by inhibiting the human IKKbeta enzyme. Additionally, IKK2-IN-4 has shown activity against the SARS-CoV-2 virus, inhibiting the 3CL-Pro protease by 18.53% at a concentration of 20µM and reducing virus-induced cytotoxicity in VERO-6 cells by 0.37% at 10 µM after 48 hours of exposure. For its physicochemical properties, it has a LogD7.4 value of 2.42, indicating its lipophilicity, and an intrinsic clearance rate of 21.0 mL.min-1.g-1 in human liver microsomes, reflecting its metabolic stability. Lastly, IKK2-IN-4 exhibits cytotoxicity against human HepG2 cells, with an IC50 value of 7900.0 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
靶点活性	IKKβ:25 nM
别名	IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

化学信息

分子量	261.3
分子式	C₁₂H₁₁N₃O₂S
CAS No.	354811-10-2
Smiles	N(C(N)=O)C=1SC(=CC1C(N)=O)C2=CC=CC=C2

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 2 mg/mL (7.65 mM), Sonication is recommended.

DMSO: 30 mg/mL (114.81 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8270 mL	19.1351 mL	38.2702 mL	191.3509 mL
5 mM	0.7654 mL	3.8270 mL	7.6540 mL	38.2702 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3827 mL	1.9135 mL	3.8270 mL	19.1351 mL
20 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5675 mL
50 mM	0.0765 mL	0.3827 mL	0.7654 mL	3.8270 mL
100 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL