Enprofylline

Name: Enprofylline
Brand: TargetMol
SKU: T21389
Price: 278 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.37%

货号 T21389Cas号 41078-02-8

别名 恩丙茶碱, Enprofyllinum, Enprofilina, 3-propylxanthine, 3-n-Propylxanthine

Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。

为众多的药物研发团队赋能，

让新药发现更简单！

Enprofylline

一键复制产品信息

很棒

纯度: 98.37%

货号 T21389 别名 恩丙茶碱, Enprofyllinum, Enprofilina, 3-propylxanthine, 3-n-PropylxanthineCas号 41078-02-8

Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。

规格	价格	库存
1 mg	¥ 278	现货
5 mg	¥ 575	现货
10 mg	¥ 816	现货
25 mg	¥ 1,470	现货
50 mg	¥ 2,200	现货
100 mg	¥ 3,170	现货
200 mg	¥ 4,430	现货
1 mL x 10 mM (in DMSO)	¥ 463	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.37%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Enprofylline AI Summary

Enprofylline exhibits a range of bioactivities and binding affinities across various receptors and enzymes. It shows significant affinity for the human adenosine A2B receptor (Ki = 4730.0 nM) and moderate affinity for the human adenosine A2A receptor (Ki = 32000.0 nM), rat adenosine A3 receptor (Ki = 65000.0 nM), and human adenosine A1 receptor (Ki = 44000.0 nM). It also antagonizes the binding of [3H]-N6-(phenylisopropyl) adenosine to the adenosine A1 receptor (Ki = 81000.0 nM) and the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor (Ki = 130000.0 nM). The compound demonstrates a relaxant activity on isolated guinea pig tracheal ring chains (EC50 = 7200.0 nM) and a positive chronotropic effect on isolated guinea pig right atrium (EC15 = 18.3 µM). It shows broncho selectivity with a ratio of stimulatory activity in the right atrium to relaxant activity in tracheal muscle of 2.5 and inhibits c-AMP phosphodiesterase activity in guinea pig tracheal muscle (Ki = 43100.0 nM). In in vivo studies, Enprofylline reduces acetylcholine-induced bronchospasm in guinea pigs (ED50 = 25.7 mg·kg-1) and causes a positive chronotropic effect (ED15 = 95.1 mg·kg-1). It also exhibits moderate permeability in human skin with a log Pe value of -0.77 and demonstrates slightly lipophilic properties with a log D value of 0.27. Moreover, Enprofylline shows varying degrees of plasma protein binding across different species, with values of 60.77% in dog plasma, 67.12% in human plasma, and 78.79% in rat plasma. Additionally, it exhibits weak inhibitory effects on human BSEP (IC50 > 1000000 nM) and moderate antiviral activity against SARS-CoV-2 at 10 µM concentration. Overall, Enprofylline is a versatile bioactive compound with distinct affinity and antagonistic effects on various adenosine receptors, modest broncho-selective relaxant activity, and a range of additional pharmacological effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sickle cell disease, diabetic neuropathy, and cerebrovascular insufficiency.
靶点活性	A2B receptor:7 μM (Ki)
别名	恩丙茶碱, Enprofyllinum, Enprofilina, 3-propylxanthine, 3-n-Propylxanthine

化学信息

分子量	194.19
分子式	C₈H₁₀N₄O₂
CAS No.	41078-02-8
Smiles	CCCn1c2nc[nH]c2c(=O)[nH]c1=O
密度	1.367 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: Insoluble

DMSO: 60 mg/mL (308.98 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1496 mL	25.7480 mL	51.4960 mL	257.4798 mL
5 mM	1.0299 mL	5.1496 mL	10.2992 mL	51.4960 mL
10 mM	0.5150 mL	2.5748 mL	5.1496 mL	25.7480 mL
20 mM	0.2575 mL	1.2874 mL	2.5748 mL	12.8740 mL
50 mM	0.1030 mL	0.5150 mL	1.0299 mL	5.1496 mL
100 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5748 mL