SB-734117

Name: SB-734117
Brand: TargetMol
SKU: T9580
Price: 780 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.72%

货号 T9580Cas号 607368-97-8

SB-734117 抑制几种 HCMV 菌株的生产性复制。 SB-734117 表现出多种药理作用，是 AGC 和 CMCG 激酶组中几种蛋白质的抑制剂。

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SB-734117

一键复制产品信息

很棒

纯度: 99.72%

货号 T9580Cas号 607368-97-8

SB-734117 抑制几种 HCMV 菌株的生产性复制。 SB-734117 表现出多种药理作用，是 AGC 和 CMCG 激酶组中几种蛋白质的抑制剂。

规格	价格	库存
1 mg	¥ 780	现货
5 mg	¥ 1,750	现货
10 mg	¥ 2,590	现货
25 mg	¥ 4,120	现货
50 mg	¥ 5,590	现货
100 mg	¥ 7,500	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 1,570	现货

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纯度: 99.72%

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COA LCMS 产品操作手册

产品介绍

SB-734117 AI Summary

SB-734117 exhibits potent inhibitory activity towards MSK-1 with an IC50 value of 3.0 nM. It also demonstrates selectivity with a GSK-3 IC50 to MSK-1 IC50 ratio of 1.5 and an RSK-1 IC50 to MSK-1 IC50 ratio of 13.0. Beyond MSK-1 inhibition, SB-734117 shows notable inhibitory effects on a range of kinases: it inhibits IKK-alpha by approximately 37.5% at a 1 µM concentration, and IKK-epsilon by 25.0% at 1 µM concentration. At 10 µM concentration, it marginally inhibits Mer Kinase by 1.0%, and at a 5 µM concentration, it inhibits PIP5K1 by 15.0% (Caliper assay). Additionally, it inhibits TBK1 by approximately 36.5% at a 1 µM concentration. In PubChem BioAssays, it exhibits a potency of 32,754.0 nM for Yes1 kinase inhibition and 8,876.6 nM for inhibiting Marburg Virus entry or binding to cells. These results suggest that SB-734117 has broad inhibitory effects on various kinases at different concentrations, indicating its potential utility in biochemical and therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SB-734117 inhibits productive replication of several HCMV strains. SB-734117 exhibited polypharmacology and was an inhibitor of several proteins from the AGC and CMCG kinase groups.

化学信息

分子量	284.32
分子式	C₁₄H₁₆N₆O
CAS No.	607368-97-8
Smiles	NC=1C(C=2N(C=3C(N2)=CN=CC3)C4CCCCC4)=NON1
密度	1.60 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (175.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5172 mL	17.5858 mL	35.1716 mL	175.8582 mL
5 mM	0.7034 mL	3.5172 mL	7.0343 mL	35.1716 mL
10 mM	0.3517 mL	1.7586 mL	3.5172 mL	17.5858 mL
20 mM	0.1759 mL	0.8793 mL	1.7586 mL	8.7929 mL
50 mM	0.0703 mL	0.3517 mL	0.7034 mL	3.5172 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	1.7586 mL