Arofylline

Name: Arofylline
Brand: TargetMol
SKU: T9816
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.19%

货号 T9816Cas号 136145-07-8

别名 阿罗茶碱, LAS 31025

Arofylline (LAS 31025) 是一种 PDE4 抑制剂，可用于哮喘的研究。

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Arofylline

一键复制产品信息

很棒

纯度: 98.19%

货号 T9816 别名 阿罗茶碱, LAS 31025Cas号 136145-07-8

Arofylline (LAS 31025) 是一种 PDE4 抑制剂，可用于哮喘的研究。

规格	价格	库存
1 mg	¥ 1,300	现货
5 mg	¥ 2,920	现货
10 mg	¥ 4,320	现货
25 mg	¥ 6,880	现货
50 mg	¥ 9,330	现货
1 mL x 10 mM (in DMSO)	¥ 2,750	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

Arofylline AI Summary

Arofylline demonstrates a wide range of bioactivities across various biological pathways and processes. It acts as an activator of the NPC1 promoter and inhibits several processes including Chronic Active B-Cell Receptor Signaling, delayed death of the malarial parasite plastid, Polymerase Iota activity, binding or entry into cells for the Marburg Virus, interactions between Vif and A3F proteins, the ERG Ets/DNA interaction, and stage-specific processes of Vaccinia Orthopoxvirus. Notably, it also acts as an inverse agonist of the GLP-1 receptor. The compound exhibits antiviral activity, specifically against SARS-CoV-2, as it inhibits the virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with IC50 values exceeding 20000.0 nM and 19952.62 nM, respectively. Additionally, Arofylline inhibits SARS-CoV-2 3CL-Pro protease activity and shows moderate inhibition of human HDAC6 activity. Overall, Arofylline presents versatile bioactivity and moderate antiviral and enzymatic inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.
别名	阿罗茶碱, LAS 31025

化学信息

分子量	304.73
分子式	C₁₄H₁₃ClN₄O₂
CAS No.	136145-07-8
Smiles	O=C1N(C2=C(C(=O)N1CCC)NC=N2)C3=CC=C(Cl)C=C3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (180.49 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2816 mL	16.4080 mL	32.8159 mL	164.0797 mL
5 mM	0.6563 mL	3.2816 mL	6.5632 mL	32.8159 mL
10 mM	0.3282 mL	1.6408 mL	3.2816 mL	16.4080 mL
20 mM	0.1641 mL	0.8204 mL	1.6408 mL	8.2040 mL
50 mM	0.0656 mL	0.3282 mL	0.6563 mL	3.2816 mL
100 mM	0.0328 mL	0.1641 mL	0.3282 mL	1.6408 mL