Name: Okadaic acid ammonium salt
Brand: TargetMol
SKU: T39183
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

待询

生物活性

产品描述	Okadaic acid ammonium salt is a marine toxin that acts as an inhibitor of protein phosphatases (PP), with the highest affinity for PP2A (IC50 = 0.1–0.3 nM), while also inhibiting PP1, PP3, PP4, and PP5, but not PP2C. By increasing the phosphorylation of various proteins, it functions as a tumor promoter and induces tau protein phosphorylation, commonly used to establish Alzheimer's disease models.
靶点活性	PP2B:4000 nM (IC50), PP3:3.7-4 nM (IC50), PP1:15-50 nM (IC50), PP4:0.1 nM (IC50), PP5:3.5 nM (IC50), PP2A:0.1-0.3 nM (IC50), PP7:＞1000 nM (IC50)
体外活性	Okadaic acid ammonium salt (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3]. Okadaic acid (10 nM, 8 hours) ammonium salt increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4]. Cell Proliferation Assay[3]Cell Line: AGS, MNK-45 and Caco 2 cell lines Concentration: 0-100 nM Incubation Time: 24 h or 48 h Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内活性	Okadaic acid ammonium salt (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]. Animal Model: Female wild-type C57BL/6 mice (6 to 8 months)[5]Dosage: 100 μM Administration: Injected unilaterally to the lateral amygdala Result: Induced Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection.
别名	冈田酸铵盐

化学信息

分子量	822.046
分子式	C₄₄H₇₁NO₁₃
CAS No.	175522-42-6
Smiles	N.[H][C@]1(CC(C)=C[C@@]2(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O)O1)[C@H](C)\C=C\[C@H]1CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1 \|c:4\|
密度	no data available