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Vinpocetine
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很棒纯度: 99.98%
货号 T0167Cas号 42971-09-5
别名 长春西汀, 长春西丁, RGH-4405, Ethyl apovincaminate
Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物，是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂，并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。
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Vinpocetine
一键复制产品信息 很棒纯度: 99.98%
货号 T0167 别名 长春西汀, 长春西丁, RGH-4405, Ethyl apovincaminateCas号 42971-09-5
Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物，是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂，并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 123 | 现货 | |
| 50 mg | ¥ 163 | 现货 | |
| 100 mg | ¥ 263 | 现货 | |
| 500 mg | ¥ 849 | 现货 | |
| 1 g | ¥ 987 | 现货 | |
| 2 g | ¥ 1,170 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 179 | 现货 |
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产品介绍
Vinpocetine AI Summary
Vinpocetine demonstrates a wide array of bioactivities across various biological systems. It exhibits inhibitory activity against Phosphodiesterase 1 (PDE1) with an IC50 value of 19000 nM from bovine aorta and 30000 nM from unknown origin, and a Ki value of 14000 nM for human PDE1. The compound also shows weak inhibition of PDE3 and PDE5 with IC50 values greater than 300000 nM. It has been evaluated for acid sphingomyelinase inhibition in human H4 cells, lipid peroxidation in rat brains, memory modulation in rodents, and antiplasmodial activity with IC50 values ranging from 7943.28 nM to 12589.25 nM against Plasmodium falciparum. Vinpocetine also displays vasorelaxant effects in rat thoracic aortic rings and inhibitory activities on various enzymes like ALDH1A1, ERG, and HDAC6. Notably, it exhibits antiviral activity against SARS-CoV-2 in VERO-6 cells and inhibitory effects on the SARS-CoV-2 3CL-Pro protease.
Furthermore, Vinpocetine shows binding affinity to PDE1A and influences vertebral and femoral blood flow in dogs, with a potency ratio of 1.0 compared to vinpocetine. It inhibits transport activity of OATP1B1/1B3 transfected CHO cells and demonstrates mixed effects on the viability of various cell lines, including HEK293T, U2OS, and human fibroblasts. The compound demonstrates a log P value of 0.94 for its cationic form and 4.45 for its noncharged form, with a log D value of 0.94, indicating its distribution characteristics. Additionally, it shows stability in mouse plasma with a half-life of 13.1 hours. Overall, the diverse bioactivities of Vinpocetine suggest its potential for various pharmacological applications..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). |
| 靶点活性 | IKK:17.17 μM, PDE1:21 μM |
| 别名 | 长春西汀, 长春西丁, RGH-4405, Ethyl apovincaminate |
| 分子量 | 350.45 |
| 分子式 | C22H26N2O2 |
| CAS No. | 42971-09-5 |
| Smiles | CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)N1C1=C4C=CC=C1 |
| 密度 | 1.28 g/cm3 |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | Ethanol: 17.5 mg/mL (49.94 mM), Sonication is recommended. DMSO: 8.68 mg/mL (24.77 mM), Sonication is recommended.  | |||||||||||||||||||||||||
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DMSO/Ethanol
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
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