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BCL6-IN-6

Name: BCL6-IN-6
Brand: TargetMol
SKU: T60008
Price: 418 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.90%

货号 T60008Cas号 2408882-54-0

BCL6-IN-6 是 Bcl-6 的抑制剂，可用于关于弥漫性大 B 细胞淋巴瘤的研究。 BCL6-IN-6 阻断 Bcl-6 与其辅阻遏物的相互作用，并以剂量依赖性方式重新激活 Bcl-6 靶基因。

为众多的药物研发团队赋能，

让新药发现更简单！

BCL6-IN-6

一键复制产品信息

很棒

纯度: 98.90%

货号 T60008Cas号 2408882-54-0

规格	价格	库存
1 mg	¥ 418	现货
5 mg	¥ 1,000	现货
10 mg	¥ 1,490	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,180	现货
100 mg	¥ 4,280	现货
200 mg	¥ 5,770	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.90%

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COA HNMR LCMS 产品操作手册

产品介绍

BCL6-IN-6 AI Summary

BCL6-IN-6 exhibits significant bioactivities, including inhibition of recombinant human C-terminal GST-tagged BCL6 BTB domain with an IC50 of 470.0 nM and showing binding affinity to the human BCL6 BTB domain. It demonstrates antiproliferative activity across various human cell lines, with IC50 values between 920.0 nM to 3250.0 nM, as well as cytotoxicity with IC50 values ranging from 8130.0 nM to 32400.0 nM. Additionally, it induces apoptosis in SUDHL4 cells, displaying both early and late apoptotic effects at varying concentrations. In vivo, it inhibits germinal center formation in NP-CGG immunized C57BL/6 mice, affecting splenic GC B cells and the proportion of Tfh cells at a 10 mg/kg dose. The compound shows antiproliferative and antitumor activity against BCL-6 dependent human SU-DHL-4 cells, including those xenografted in mice, and results in increased mRNA expression of CD69, CXCR4, and ATR. Furthermore, BCL6-IN-6 is metabolically stable in human liver microsomes with a half-life greater than 1.0 hour and demonstrates high protein binding in human plasma, with a fraction unbound of 0.076..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.

化学信息

分子量	522.64
分子式	C₂₇H₃₁FN₆O₂S
CAS No.	2408882-54-0
Smiles	COc1cc(Nc2nc(ncc2F)N2C[C@H](C)N[C@H](C)C2)ccc1NC(=O)c1ccc(s1)C1=CCCC1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 5.23 mg/mL (10 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9134 mL	9.5668 mL	19.1336 mL	95.6681 mL
5 mM	0.3827 mL	1.9134 mL	3.8267 mL	19.1336 mL
10 mM	0.1913 mL	0.9567 mL	1.9134 mL	9.5668 mL

计算器

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。