Anti-LIFR Antibody (7Q32)

Name: Anti-LIFR Antibody (7Q32)
Brand: TargetMol
SKU: TMAY-01040
Rating: 4.5 (1 reviews)

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产品编号 TMAY-01040

Anti-LIFR Antibody (7Q32) 是一种 Rabbit 抗体，靶向 LIFR。Anti-LIFR Antibody (7Q32) 可用于 IHC-P。

Anti-LIFR Antibody (7Q32)

还可以

产品编号 TMAY-01040

Anti-LIFR Antibody (7Q32) 是一种 Rabbit 抗体，靶向 LIFR。Anti-LIFR Antibody (7Q32) 可用于 IHC-P。

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生物活性

产品描述	Anti-LIFR Antibody (7Q32) is a Rabbit antibody targeting LIFR. Anti-LIFR Antibody (7Q32) can be used in IHC-P.
Ig Type	Monoclonal Rabbit IgG
克隆号	7Q32
交叉反应	Human
验证活性	Immunochemical staining of human LIFR in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast.
应用	IHC-P
推荐剂量	IHC-P: 1:100-1:500
抗体种类	Monoclonal
宿主来源	Rabbit
构建方式	This antibody was obtained from a rabbit immunized with purified, recombinant Human LIFR / CD118 (rh LIFR; TMPY-00991; NP_001121143.1; Met 1-Ser 833).
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human LIFR protein (TMPY-00991)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.