首页工具

Tubulin polymerization-IN-4

产品编号 T61940

Tubulin polymerization-IN-4 是有效的微管蛋白聚合体 (tubulin polymerization) 抑制剂（IC50=4.6 μM）。Tubulin polymerization-IN-4 可以破坏微管蛋白聚合，将细胞周期阻滞在G2/M 期，诱导细胞凋亡 (apoptosis)，抑制细胞的克隆发生和迁移。Tubulin polymerization-IN-4还可以破坏血管系统。

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

Tubulin polymerization-IN-4, CAS N/A

规格	价格/CNY	货期
25 mg	￥ 10,600	10-14周
50 mg	￥ 13,800	10-14周
100 mg	￥ 17,500	10-14周

大包装超大折扣，点击咨询

该分子属于定制产品。陶术拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。但由于客观因素，研发中会存在小概率合成不成功的情况，还请理解，如您有任何问题，欢迎咨询，我们将竭诚为您服务。

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

产品描述	Tubulin polymerization-IN-4 is an effective inhibitor of tubulin polymerization (IC50=4.6 μM）。 Tubulin polymerization-IN-4 can destroy tubulin polymerization, block cell cycle at G2/M phase, induce apoptosis, and inhibit cell cloning and migration. Tubulin polymerization-IN-4 can also damage the vascular system.
体外活性	Tubulin polymerization-IN-4 (compound 9j) (0-1 μM; 48 hours) exhibits sub-micromolar inhibitory activities against HeLa, SiHa and MS751 [1]. Tubulin polymerization-IN-4 (3, 6 and 12.5 μM; 0-20 min) inhibits tubulin polymerization in a concentration-dependent manner with the inhibition percentages of 39%, 54%, and 77% at 3, 6 and 12.5 μM [1]. Tubulin polymerization-IN-4 (1-100 μM; 2 hours) inhibits the formation of EBI-β-tubulin adduct in a concentration-dependent manner [1]. Tubulin polymerization-IN-4 (0.2 μM; 1 and 2 hours) disrupts the HUVEC-formed vascular tube [1]. Tubulin polymerization-IN-4 (0.1-0.4 μM; 24 hours) increases cell distribution to the G2/M phase in a concentration-dependent manner [1]. Tubulin polymerization-IN-4 (0.1-0.4 μM; 24 hours) induces apoptosis of HeLa cells [1]. Tubulin polymerization-IN-4 (20, 50, 100 nM; 14 days) reduces new colony formation and suppresses HeLa cell growth for 14 days in a dose-dependent manner [1]. Tubulin polymerization-IN-4 (0.1, 0.2 and 0.4 μM; 24 hours) effectively inhibits the migration of HeLa cells in a concentration-dependent manner [1]. Tubulin polymerization-IN-4 (0-200 μM; 24 hours) exhibits good renal safety profile, with IC 50 of 188 ± 16 μM in HK-2 cells [1]. Cell Proliferation Assay Cell Line: HeLa, SiHa and MS751 [1] Concentration: 0-1 μM Incubation Time: 48 hours Result: Exhibited sub-micromolar inhibitory activities against HeLa, SiHa and MS751 with IC 50 s of 0.09 ± 0.02 μM, 0.15 ± 0.01 μM, 0.11 ± 0.03 μM. Cell Cycle Analysis Cell Line: HeLa cells [1] Concentration: 0.1, 0.2 and 0.4 μM Incubation Time: 24 hours Result: Increased cell distribution to the G2/M phase in a concentration-dependent way, arresting 24.7%, 47.6% and 71.7% of the cells in this phase at 0.1, 0.2 and 0.4 μM, respectively. Apoptosis Analysis Cell Line: HeLa cells [1] Concentration: 0.1, 0.2 and 0.4 μM Incubation Time: 24 hours Result: Induced 35.9%, 66.4% and 84.4% of cell population undergoing apoptosis at 0.1 μM, 0.2 μM, 0.4 μM, respectively. Cell Cytotoxicity Assay Cell Line: HK-2 cells [1] Concentration: 0-200 μM Incubation Time: 24 hours Result: Exhibited good renal safety profile, with IC 50 of 188 ± 16 μM in HK-2 cells.
体内活性	Tubulin polymerization-IN-4 (100-1000 mg/kg; IP, single) exhibits extremely low toxicity with LD 50 over 1000 mg/kg [1]. Tubulin polymerization-IN-4 (30 and 60 mg/kg; IP; daily for 21 days) inhibits the tumor growth, with TGI of 35% and 58% at dosing 30 and 60 mg/kg [1]. Tubulin polymerization-IN-4 (30 mg/kg; IP; single) presents the modest pharmacokinetic properties [1]. Pharmacokinetic Parameters of Tubulin polymerization-IN-4 in ICR mice [1]. IP (30 mg/kg) T 1/2 (h) 1.56 ± 0.28 T max (h) 0.25 C max (μg/L) 6215 ± 308 AUC 0-t (μg/L·h) 5609 ± 347 AUC 0-∞ (μg/L·h) 5940 ± 347 V Z /F (L/kg) 11.35 ± 1.29 CL Z /F (L/h/kg) 5.05 ± 0.91 MRT (h) 1.77 ± 0.43

分子量	400.86
分子式	C21H21ClN2O4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +