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Chlorotrianisene

Name: Chlorotrianisene
Brand: TargetMol
SKU: T2569
Price: 473 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.03%

货号 T2569Cas号 569-57-3

别名 氯烯雌醚, 氯丁烯二烯, tris(p-methoxyphenyl)chloroethylene, tri-p-anisylchloroethylene, TACE, CTA

Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂，有雌激素活性，也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。

为众多的药物研发团队赋能，

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Chlorotrianisene

一键复制产品信息

很棒

纯度: 99.03%

货号 T2569 别名 氯烯雌醚, 氯丁烯二烯, tris(p-methoxyphenyl)chloroethylene, tri-p-anisylchloroethylene, TACE, CTACas号 569-57-3

规格	价格	库存
1 mg	¥ 473	现货
5 mg	¥ 1,130	现货
10 mg	¥ 1,680	现货
25 mg	¥ 3,000	现货
50 mg	¥ 4,200	现货
100 mg	¥ 5,980	现货
200 mg	¥ 8,270	现货
1 mL x 10 mM (in DMSO)	¥ 1,250	现货

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实验操作小课堂

常见问题解答

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纯度: 99.03%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Chlorotrianisene AI Summary

Chlorotrianisene exhibits a wide range of bioactivities, impacting various cellular and molecular pathways. It has shown potency in modulating Lamin A Splicing (281.8 nM) and SMN2 splice variant expression, as well as acting as an inhibitor of HSD17B4 with a potency of 39810.7 nM. Chlorotrianisene affects cell viability and metabolic activity in several cell assays, including a significant inhibition index of 0.9163 in Vero E6 cells infected with SARS-CoV-2. Moreover, it has demonstrated inhibitory activity against JMJD2E, Cruzain enzymes, and proteins like USP1/UAF1, TDP1, and ATXN, along with influencing receptors such as the Thyroid Stimulating Hormone Receptor and ERK Signaling Pathway. It exhibits strong inhibitory effects on OATP1B1 and OATP1B3 transport proteins in CHO cells with inhibition percentages of 91.3% and 92.54%, respectively, at 10 µM. Additionally, Chlorotrianisene shows antiviral activity against SARS-CoV-2, inhibiting the virus's induced cytotoxicity in Caco-2 and VERO-6 cells with moderate effects. It also inhibits SARS-CoV-2 3CL-Pro protease by 1.504% at 20µM. In various assays, Chlorotrianisene has recorded weak or no significant interactions, except for a modest binding affinity towards human ESR1 (AC50 of 817.1 nM) and inhibition of rat Ptgs1 (AC50 values of 78.2 nM and 259.2 nM). Notably, it shows 29.89% inhibition of human HDAC6 activity in enzymatic assays. Overall, Chlorotrianisene demonstrates a broad spectrum of bioactivities that necessitate further investigations to unlock its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.
别名	氯烯雌醚, 氯丁烯二烯, tris(p-methoxyphenyl)chloroethylene, tri-p-anisylchloroethylene, TACE, CTA

化学信息

分子量	380.86
分子式	C₂₃H₂₁ClO₃
CAS No.	569-57-3
Smiles	COc1ccc(cc1)C(Cl)=C(c1ccc(OC)cc1)c1ccc(OC)cc1
密度	1.1010 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (144.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.25 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6256 mL	13.1282 mL	26.2564 mL	131.2818 mL
5 mM	0.5251 mL	2.6256 mL	5.2513 mL	26.2564 mL
10 mM	0.2626 mL	1.3128 mL	2.6256 mL	13.1282 mL
20 mM	0.1313 mL	0.6564 mL	1.3128 mL	6.5641 mL
50 mM	0.0525 mL	0.2626 mL	0.5251 mL	2.6256 mL
100 mM	0.0263 mL	0.1313 mL	0.2626 mL	1.3128 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Chlorotrianisene

Chlorotrianisene

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Chlorotrianisene

Chlorotrianisene