Name: MRTX9768 hydrochloride
Brand: TargetMol
SKU: T36630
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

¥ 7,150

待询

10 mg

¥ 11,400

待询

生物活性

产品描述	MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1].
体外活性	MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1].MRTX9768 selectively targets MTAP/CDKN2A-deleted tumors[2][1].
体内活性	In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow[1].

化学信息

Smiles

#N/A

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 40 mg/mL, Sonication is recommended. DMSO: 90 mg/mL, Sonication is recommended.
体内实验配方	10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL, Sonication is recommeded. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

MRTX9768 hydrochloride