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JNJ-40411813

Name: JNJ-40411813
Brand: TargetMol
SKU: TQ0094
Price: 491 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.74%

货号 TQ0094Cas号 1127498-03-6

别名 ADX-71149

JNJ-40411813 (ADX-71149) 是一种新型 mGlu2R 正变构调节剂，EC50 值为 147 nM。

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JNJ-40411813

一键复制产品信息

很棒

纯度: 99.74%

货号 TQ0094 别名 ADX-71149Cas号 1127498-03-6

JNJ-40411813 (ADX-71149) 是一种新型 mGlu2R 正变构调节剂，EC50 值为 147 nM。

规格	价格	库存
1 mg	¥ 491	现货
5 mg	¥ 1,190	现货
10 mg	¥ 1,890	现货
25 mg	¥ 2,970	现货
50 mg	¥ 4,130	现货
100 mg	¥ 5,680	现货
200 mg	¥ 7,680	现货
1 mL x 10 mM (in DMSO)	¥ 935	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.74%

颜色: 白色

性状: Solid

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

JNJ-40411813 AI Summary

JNJ-40411813 acts as a positive allosteric modulator of the human mGlu2 receptor, with an EC50 of 147.0 nM and Emax of 273.0% for the wild-type receptor. It shows selectivity for the mGlu2 receptor over other receptors, including 5HT receptors, although it does exhibit antagonism at the 5HT2A receptor and inhibits the human ERG channel. It demonstrates moderate to high metabolic stability in liver microsomes, high plasma protein binding across multiple species, and moderate oral bioavailability and apparent permeability in Caco2 cells. The compound has a high log P value of 4.6, indicating significant lipophilicity, and displays bioactivity in rat sleep-wake EEG paradigms, affecting the sleep-wake cycle. It also exhibits weak to moderate antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity of VERO-6 and Caco-2 cells at a concentration of 10 µM, albeit with low efficacy. Additionally, JNJ-40411813 shows inhibitory activity against human HDAC6, with around 59.91% inhibition in enzymatic assays. Collectively, the therapeutic indices suggest a favorable balance between efficacy and safety in various models, making it a compound of interest for further pharmacological studies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
靶点活性	mGluR2:147 nM (EC50)
别名	ADX-71149

化学信息

分子量	344.88
分子式	C₂₀H₂₅ClN₂O
CAS No.	1127498-03-6
Smiles	CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O
密度	1.18 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 24 mg/mL (69.59 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8996 mL	14.4978 mL	28.9956 mL	144.9780 mL
5 mM	0.5799 mL	2.8996 mL	5.7991 mL	28.9956 mL
10 mM	0.2900 mL	1.4498 mL	2.8996 mL	14.4978 mL
20 mM	0.1450 mL	0.7249 mL	1.4498 mL	7.2489 mL
50 mM	0.0580 mL	0.2900 mL	0.5799 mL	2.8996 mL

计算器

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。