规格

价格

库存

数量

1 mg

¥ 328

现货

5 mg

¥ 745

现货

10 mg

¥ 1,090

现货

25 mg

¥ 1,970

现货

50 mg

¥ 2,880

现货

100 mg

¥ 3,970

现货

1 mL x 10 mM (in DMSO)

¥ 797

现货

生物活性

产品描述	Asciminib hydrochloride is described as a "STAMP inhibitor," specifically targeting the ABL myristoyl pocket, Asciminib hydrochloride, marketed as Scemblix, are applied in research in Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) by binding to the allosteric site of wild-type ABL N-terminus, which is myristoylated, whereas the ABL fusion protein lacks this domain, enabling selective modulation of oncogenic signaling pathways and serving as a targeted therapeutic tool in hematologic cancer research.
体外活性	Asciminib hydrochloride（0.5 μM）的预处理1小时并未干扰4-OH-Cy在MCF7细胞中诱导的DNA损伤应答信号。Asciminib hydrochloride预处理组与单独4-OH-Cy处理组相比，磷酸化ATM（p-ATM）、γH2AX以及磷酸化p53等DNA损伤标志蛋白的表达水平无显著差异 [2]。
体内活性	在针对幼鼠（P6-P7日龄）的动物实验中，通过腹腔注射方式给予Asciminib hydrochloride（0.1–0.5 mg/kg）与环磷酰胺（100 mg/kg）联合处理，以评估其对卵巢储备的保护作用。实验结果显示，Asciminib hydrochloride在0.25 mg/kg剂量下能显著减轻Cy诱导的DNA损伤应激信号，表现为抑制TAp63蛋白修饰、降低γH2AX及磷酸化DNA-PK等DNA损伤应答标志物的表达，并减少卵母细胞中cleaved PARP的活化。同时，Asciminib hydrochloride还抑制了Akt在卵泡储备细胞中的磷酸化，表明其对Cy引发的卵泡过度激活具有调控作用 [2]。
别名	盐酸阿西米尼, ABL-001 hydrochloride, ABL001 hydrochloride

化学信息

分子量	486.3
分子式	C₂₀H₁₉Cl₂F₂N₅O₃
CAS No.	2119669-71-3
Smiles	C(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3CC[C@@H](O)C3)C=4C=CNN4.Cl
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble)

DMSO: 80 mg/mL (164.51 mM), Sonication is recommeded.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0563 mL	10.2817 mL	20.5634 mL	102.8172 mL
5 mM	0.4113 mL	2.0563 mL	4.1127 mL	20.5634 mL
10 mM	0.2056 mL	1.0282 mL	2.0563 mL	10.2817 mL
20 mM	0.1028 mL	0.5141 mL	1.0282 mL	5.1409 mL
50 mM	0.0411 mL	0.2056 mL	0.4113 mL	2.0563 mL
100 mM	0.0206 mL	0.1028 mL	0.2056 mL	1.0282 mL