Nimustine Hydrochloride

Name: Nimustine Hydrochloride
Brand: TargetMol
SKU: T5017
Price: 185 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.80%

货号 T5017Cas号 55661-38-6

别名 盐酸尼莫司汀, Nidran hydrochloride

Nimustine Hydrochloride (Nidran hydrochloride) 是一种 DNA 交联剂和 DNA 烷基化剂，能诱导 DNA 复制损伤和 DNA 双链断裂，抑制DNA 合成，已用于研究胶质母细胞瘤治疗的试验。

Nimustine Hydrochloride

一键复制产品信息

很棒

纯度: 98.80%

货号 T5017 别名 盐酸尼莫司汀, Nidran hydrochlorideCas号 55661-38-6

规格	价格	库存
1 mg	¥ 185	现货
5 mg	¥ 397	现货
10 mg	¥ 662	现货
25 mg	¥ 1,230	现货
50 mg	¥ 1,760	现货
100 mg	¥ 2,820	现货
1 mL x 10 mM (in DMSO)	¥ 398	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.80%

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产品介绍

Nimustine Hydrochloride AI Summary

Nimustine Hydrochloride exhibits bioactivities as an inhibitor in various assays, including AmpC Beta-Lactamase with a potency of 11220.2 nM, Polymerase Iota with a potency of 19952.6 nM, Hepatitis C Virus with a potency of 2818.4 nM, and the HIV-1 protein Vpr with a potency of 891.3 nM. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 20596.2 nM both in absence and presence of CPT, and antagonizes cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2) with a potency of 89125.1 nM. Furthermore, Nimustine Hydrochloride exhibits cytotoxicity against human U87MG cells, with an IC50 value of 720.0 nM, indicating its effectiveness in inhibiting the growth or viability of these cells as assessed by the MTT assay after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
别名	盐酸尼莫司汀, Nidran hydrochloride

化学信息

分子量	309.15
分子式	C₉H₁₄Cl₂N₆O₂
CAS No.	55661-38-6
Smiles	Cl.Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (177.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2347 mL	16.1734 mL	32.3468 mL	161.7338 mL
5 mM	0.6469 mL	3.2347 mL	6.4694 mL	32.3468 mL
10 mM	0.3235 mL	1.6173 mL	3.2347 mL	16.1734 mL
20 mM	0.1617 mL	0.8087 mL	1.6173 mL	8.0867 mL
50 mM	0.0647 mL	0.3235 mL	0.6469 mL	3.2347 mL
100 mM	0.0323 mL	0.1617 mL	0.3235 mL	1.6173 mL