p38 MAPK

p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinases. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1.

Cat. No.	Product Name	CAS No.	Purity
T68134	Ro-3201195 化合物Ro-3201195	249937-52-8	98%
T68134	Ro-3201195是一种新型可口服的p38 MAPK 抑制剂，具有很高的选择性。
T36010	P38 MAPK Inhibitor 化合物p38 MAPK抑制剂	219138-24-6	98%
T36010	p38 MAPK Inhibitor 是p38 MAPK 激酶的有效抑制剂（IC50＝ 35 nM）。p38 MAPK Inhibitor 抑制癌基因RAS 诱导的衰老。
T41142	EM 163 化合物EM 163	1206480-93-4	98%
T41142	EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在...
T27627	Iroxanadine 化合物Iroxanadine	203805-20-3	98%
T27627	Iroxanadine 是一种新型小分子MAPK p38 抑制剂，诱导p38 SAPK 的磷酸化，在用去氧肾上腺素预先收缩的豚鼠肺动脉制剂中诱导浓度依赖性松弛，可用于治疗动脉粥样硬化、糖尿病血管病，微血管心绞痛和外周动脉疾病等血管疾病。
T68139	Scio-323 化合物Scio-323	309913-51-7	98%
T68139	Scio-323是一种可口服的 p38丝裂原活化蛋白（MAPK）激酶抑制剂。
T38665	OVA-E1 peptide TFA 化合物OVA-E1 peptide TFA	1262750-80-0	98%
T38665	OVA-E1 peptide TFA 在突变型和野生型胸腺细胞中都能同样地激活 p38 和 JNK 级联。
TN3404	Altholactone 化合物 TN3404	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN4394	Kobophenol A 化合物 TN4394	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN3042	4-Hydroxycinnamamide 化合物 TN3042	194940-15-3	98%
TN3042	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN4938	Samidin 化合物 TN4938	477-33-8	98%
TN4938	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN4317	Isopedicin 化合物 TN4317	4431-42-9	98%
TN4317	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T7162	R1487 Hydrochloride 化合物R1487 (Hydrochloride)	449808-64-4	98%
T7162	R1487 Hydrochloride 是一种可口服的高选择性 p38α 抑制剂，对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
T10298	AMG-548 hydrochloride (864249-60-5 free base) 化合物 T10298	T10298	98%
T10298	AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective a...
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1751	Hydroxycitric acid 2-羟基柠檬酸	6205-14-7	98%
TN1751	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1347	8-Prenylkaempferol 化合物8-Prenylkaempferol	28610-31-3	98%
TN1347	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN4986	Selinidin 化合物 TN4986	19427-82-8	98%
TN4986	Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TN5174	Trichosanatine 化合物 TN5174	169626-16-8	98%
TN5174	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...