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ML281

Name: ML281
Brand: TargetMol
SKU: T3423
Price: 297 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T3423Cas号 1404437-62-2 一键复制产品信息纯度: 99.87%

很棒

ML281是高效的STK33选择性抑制剂(IC50:14 nM)。

ML281

一键复制产品信息

很棒

纯度: 99.87%

货号 T3423Cas号 1404437-62-2

ML281是高效的STK33选择性抑制剂(IC50:14 nM)。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 297	现货
5 mg	¥ 679	现货
10 mg	¥ 993	现货
25 mg	¥ 1,820	现货
50 mg	¥ 2,920	现货
100 mg	¥ 4,130	现货
200 mg	¥ 5,880	现货
1 mL x 10 mM (in DMSO)	¥ 579	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.87%

颜色: 白色

性状: Solid

资源下载: COA LCMS HPLC HNMR产品操作手册

产品介绍

ML281 AI Summary

ML281 exhibits significant bioactivity and selectivity features, comprising metabolic stability with degradation rates of 10.0% in mouse plasma and 80.3% in human plasma after 5 hours. It shows high plasma protein binding in both mouse (99.9%) and human (99.6%) plasma. The solubility of ML281 in PBS at pH 7.4 is 5800.0 nM. In terms of enzymatic inhibition, ML281 demonstrates potent inhibition of N-terminal 6His-tagged full-length human recombinant STK33 with an IC50 value of 14.0 nM, using myelin basic protein as substrate. It also inhibits human KDR and FLT3 at 1 µM, with inhibition percentages of ≥25.0% for each. The compound shows a high IC50 value (>10,000.0 nM) for inhibition of His-tagged recombinant catalytic fragment of PKA, translating to a selectivity ratio of IC50 for PKA to STK33 of >700.0. Additionally, it shows selectivity for STK33 over Aurora kinase B with a ratio IC50 of 550.0. Regarding its antiviral activity, ML281 inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 µM after 48 hours, showing 5.22% inhibition as determined by high content imaging. It also exhibits SARS-CoV-2 3CL-Pro protease inhibition activity with 6.1% and 31.01% inhibition at a concentration of 20 µM. However, its inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus shows minimal effects with percentages of 0.19% and -0.06% in different assays. Furthermore, ML281 shows significant inhibition of the human HDAC6 enzyme, particularly demonstrating 40.5% inhibition using a commercial peptide substrate and 4.16% inhibition using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
靶点活性	STK33:14 nM.

化学信息

分子量	389.47
分子式	C₂₂H₁₉N₃O₂S
CAS No.	1404437-62-2
Smiles	CC(C)c1ccc(NC(=O)c2cccs2)c(c1)-c1nc2ccccc2[nH]c1=O
密度	no data available

储存&溶解度

存储

Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (128.38 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5676 mL	12.8380 mL	25.6759 mL	128.3796 mL
5 mM	0.5135 mL	2.5676 mL	5.1352 mL	25.6759 mL
10 mM	0.2568 mL	1.2838 mL	2.5676 mL	12.8380 mL
20 mM	0.1284 mL	0.6419 mL	1.2838 mL	6.4190 mL
50 mM	0.0514 mL	0.2568 mL	0.5135 mL	2.5676 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2838 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。