Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. The administration of Revizinone improved the hemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance, and a stable heart rate and mean arterial blood pressure. With regard to the reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer) [1] [2][4].