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Mafenide hydrochloride

Name: Mafenide hydrochloride
Brand: TargetMol
SKU: T1026
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochloride

货号 T1026Cas号 138-37-4 一键复制产品信息纯度: 98.34%

很棒

Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) 是一种有效的磺酰胺类抗菌剂，可用于烧伤创面。它通过抑制核苷酸合成，对革兰氏阳性和革兰氏阴性生物均具有活性。

Mafenide hydrochloride

一键复制产品信息

很棒

纯度: 98.34%

货号 T1026Cas号 138-37-4

别名 盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochloride

规格	价格	库存
25 mg	¥ 289	现货
50 mg	¥ 413	现货
100 mg	¥ 578	现货
200 mg	¥ 849	现货
500 mg	¥ 1,420	现货
1 mL x 10 mM (in DMSO)	¥ 166	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.34%

颜色: 白色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Mafenide hydrochloride AI Summary

Mafenide hydrochloride exhibits a broad spectrum of bioactivities, including the inhibition of tau fibril formation, inducing DNA re-replication in SW480 colon adenocarcinoma cells, and inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also shows efficacy in blocking Ebola virus entry and modulating insulin secretion in INS-1E cells. This compound demonstrates significant potency in both nanomolar and micromolar ranges across various assays. In addition to its antiviral properties, Mafenide hydrochloride inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, achieving inhibition rates of 81.65% and 85.4% at a 10 µM concentration, respectively. It also acts as an inhibitor of human carbonic anhydrase enzymes, displaying greater potency against carbonic anhydrase 1 (Ki = 170.0 nM) relative to carbonic anhydrase 2 (Ki = 25000.0 nM). Specifically related to SARS-CoV-2, Mafenide hydrochloride exhibits weak activity in preventing cell death in Vero E6 cells, with a very low inhibition index of 0.01527. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and Vero-6 cells, with inhibition rates of -2.65% and 0.12%, respectively, at 10 µM after 48 hours exposure. Additionally, the compound inhibits the SARS-CoV-2 3CL-Pro protease by 17.39% at a concentration of 20 µM, as measured by a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
别名	盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochloride

化学信息

分子量	222.69
分子式	C₇H₁₁ClN₂O₂S
CAS No.	138-37-4
Smiles	Cl.NCc1ccc(cc1)S(=O)(=O)N
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 197.6 mM, Sonication is recommended.

DMSO: 55 mg/mL (246.98 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4905 mL	22.4527 mL	44.9055 mL	224.5274 mL
5 mM	0.8981 mL	4.4905 mL	8.9811 mL	44.9055 mL
10 mM	0.4491 mL	2.2453 mL	4.4905 mL	22.4527 mL
20 mM	0.2245 mL	1.1226 mL	2.2453 mL	11.2264 mL
50 mM	0.0898 mL	0.4491 mL	0.8981 mL	4.4905 mL
100 mM	0.0449 mL	0.2245 mL	0.4491 mL	2.2453 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Mafenide hydrochloride Mafenide Inhibitor inhibit CarbonicAnhydrase Carbonic anhydrase VI Carbonic Anhydrase Bacterial Antibiotic 4-Aminomethylbenzenesulfonamide Hydrochloride

Mafenide hydrochloride

Mafenide hydrochloride