Mafenide hydrochloride

Name: Mafenide hydrochloride
Brand: TargetMol
SKU: T1026
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.34%

货号 T1026Cas号 138-37-4

别名 盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochloride

Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) 是一种有效的磺酰胺类抗菌剂，可用于烧伤创面。它通过抑制核苷酸合成，对革兰氏阳性和革兰氏阴性生物均具有活性。

Mafenide hydrochloride

一键复制产品信息

很棒

纯度: 98.34%

货号 T1026 别名 盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochlorideCas号 138-37-4

规格	价格	库存
25 mg	¥ 289	现货
50 mg	¥ 413	现货
100 mg	¥ 578	现货
200 mg	¥ 849	现货
500 mg	¥ 1,420	现货
1 mL x 10 mM (in DMSO)	¥ 166	现货

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纯度: 98.34%

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产品介绍

Mafenide hydrochloride AI Summary

Mafenide hydrochloride exhibits a broad spectrum of bioactivities, including the inhibition of tau fibril formation, inducing DNA re-replication in SW480 colon adenocarcinoma cells, and inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also shows efficacy in blocking Ebola virus entry and modulating insulin secretion in INS-1E cells. This compound demonstrates significant potency in both nanomolar and micromolar ranges across various assays. In addition to its antiviral properties, Mafenide hydrochloride inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, achieving inhibition rates of 81.65% and 85.4% at a 10 µM concentration, respectively. It also acts as an inhibitor of human carbonic anhydrase enzymes, displaying greater potency against carbonic anhydrase 1 (Ki = 170.0 nM) relative to carbonic anhydrase 2 (Ki = 25000.0 nM). Specifically related to SARS-CoV-2, Mafenide hydrochloride exhibits weak activity in preventing cell death in Vero E6 cells, with a very low inhibition index of 0.01527. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and Vero-6 cells, with inhibition rates of -2.65% and 0.12%, respectively, at 10 µM after 48 hours exposure. Additionally, the compound inhibits the SARS-CoV-2 3CL-Pro protease by 17.39% at a concentration of 20 µM, as measured by a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
别名	盐酸磺胺米隆, 4-Aminomethylbenzenesulfonamide hydrochloride

化学信息

分子量	222.69
分子式	C₇H₁₁ClN₂O₂S
CAS No.	138-37-4
Smiles	Cl.NCc1ccc(cc1)S(=O)(=O)N
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 197.6 mM, Sonication is recommended.

DMSO: 55 mg/mL (246.98 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4905 mL	22.4527 mL	44.9055 mL	224.5274 mL
5 mM	0.8981 mL	4.4905 mL	8.9811 mL	44.9055 mL
10 mM	0.4491 mL	2.2453 mL	4.4905 mL	22.4527 mL
20 mM	0.2245 mL	1.1226 mL	2.2453 mL	11.2264 mL
50 mM	0.0898 mL	0.4491 mL	0.8981 mL	4.4905 mL
100 mM	0.0449 mL	0.2245 mL	0.4491 mL	2.2453 mL