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L-Carnitine

Name: L-Carnitine
Brand: TargetMol
SKU: T0846
Price: 310 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 左旋肉碱, Levocarnitine, L(-)-Carnitine

货号 T0846Cas号 541-15-1 一键复制产品信息纯度: 99.97%

很棒

L-Carnitine (L(-)-Carnitine) 是一种人内源性分子，在人体内以蛋氨酸和赖氨酸为底物进行生物合成，并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。

L-Carnitine

一键复制产品信息

很棒

纯度: 99.97%

货号 T0846Cas号 541-15-1

别名 左旋肉碱, Levocarnitine, L(-)-Carnitine

规格	价格	库存
500 mg	¥ 310	现货
1 g	¥ 341	现货
5 g	¥ 436	现货
10 g	¥ 756	现货
25 g	¥ 1,250	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.97%

颜色: 白色

资源下载: COA LCMS HNMR产品操作手册

产品介绍

L-Carnitine AI Summary

L-Carnitine exhibits a wide array of bioactivities and possesses significant potential in various biological systems. It is known for its effects on carnitine acyltransferases and carnitine palmitoyltransferases, showing specific kinetic constants and inhibitory effects in animal models and neonatal rat cardiac myocytes. The compound also demonstrates binding affinity to bovine serum albumin, particularly in the presence of Fe3+, and exhibits dose-dependent cytotoxicity against human HL60 and K562 cells. Furthermore, L-Carnitine shows permeability of 1.3 x 10^-6 cm/s at pH 6.5 and an oral bioavailability of 10.0% in humans. In terms of enzyme interaction, it is a potent inhibitor of AmpC Beta-Lactamase, induces genotoxicity and DNA re-replication, inhibits ELG1-dependent DNA repair, and acts against malaria by targeting the parasite plastid. Its potential impact on liver function is indicated by increases in various liver enzymes, and it shows transport activity with a Km value of 61.9 nM in mOat3-expressing oocytes. Despite its varied bioactivities, L-Carnitine has a DILI severity class of 0.0, suggesting no significant drug-induced liver injury. Additionally, L-Carnitine exhibits antiviral activity against SARS-CoV-2, albeit with weak potency, and does not show significant bioactivity against a range of tested receptors and enzymes, as indicated by AC50 values greater than 30000.0 nM. The totality of these findings points to its complex interaction profile with multiple biological pathways and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.
别名	左旋肉碱, Levocarnitine, L(-)-Carnitine

化学信息

分子量	161.2
分子式	C₇H₁₅NO₃
CAS No.	541-15-1
Smiles	C([N+](C)(C)C)[C@@H](CC([O-])=O)O
密度	0.64 g/cm3

储存&溶解度

存储

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 6.25 mg/mL (38.77 mM), Sonication is recommended.

H2O: 29.00 mg/mL (179.90 mM), Sonication is recommended.

Ethanol: 30.00 mg/mL (186.10 mM), Sonication is recommended.

溶液配制表

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	310.1737 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	62.0347 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
20 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL

H2O/Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
100 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

mitochondria metabolism metabolic L-Carnitine LCarnitine L Carnitine Inhibitor inhibit imbalance FattyAcidSynthase Fatty Acid Synthase fatty FAS EndogenousMetabolite Endogenous Metabolite endogenous acid (R)-Carnitine

L-Carnitine

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产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词